Unusual flavoenzyme catalysis in marine bacteria.
Unusual flavoenzyme catalysis in marine bacteria.
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DOI：
10.1016/j.cbpa.2016.01.001
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发表时间：
2016-04
影响因子：
7.8
通讯作者：
Moore BS
中科院分区：
文献类型：
--
作者：
Teufel R;Agarwal V;Moore BS
自从80多年前黄素辅因子被发现以来，黄素依赖的酶已经成为初级代谢中普遍存在的、用途广泛的氧化还原催化剂。然而，最近在次级代谢途径的发现和表征方面的进展揭示了黄素介导的催化在产生结构复杂的天然产物中的新作用。在这里，我们回顾了从海洋细菌次生代谢中选择的关键生物合成黄素酶，并说明了它们的功能和机制研究如何扩大了我们对辅因子的化学成分的看法，并导致了以前未知的黄素氧化还原状态的发现。
Ever since the discovery of the flavin cofactor more than 80 years ago, flavin-dependent enzymes have emerged as ubiquitous and versatile redox catalysts in primary metabolism. Yet, the recent advances in the discovery and characterization of secondary metabolic pathways exposed new roles for flavin-mediated catalysis in the generation of structurally complex natural products. Here, we review a selection of key biosynthetic flavoenzymes from marine bacterial secondary metabolism and illustrate how their functional and mechanistic investigation expanded our view of the cofactor's chemical repertoire and led to the discovery of a previously unknown flavin redox state.