Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization
Pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization
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DOI：
10.1016/j.fertnstert.2015.11.019
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发表时间：
2016-03-01
影响因子：
6.7
通讯作者：
Greenblatt, Ellen
中科院分区：
文献类型：
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作者：
Sterling, Lynn;Liu, Jennifer;Greenblatt, Ellen
目的：确定多囊卵巢综合征（PCOS）的诊断是否独立地预测了妊娠并发症发生率相对于对照组的增加，在调整了重要的混杂因素后。设计：回顾性队列。设置：不适用。患者：回顾2006年12月至2012年12月期间新鲜IVF伴或不伴卵胞浆内单精子注射移植后的所有妊娠（n = 1，084）确定了394例符合条件的单胎分娩（71例PCOS妇女; 323例无PCOS对照）。干预：不适用。主要结果测量：评估单胎分娩的不良妊娠和出生结果。结果：在调整了年龄、产次、体重指数、和受孕时间：妊娠期糖尿病（校正比值比[AOR] 3.15，95%置信区间[CI] 1.35-7.33），妊娠期高血压疾病（AOR 4.25，95% CI 1.94-9.32），早产第90百分位数（AOR 2.77，95% CI 1.21-6.35）。早产风险增加
Objective: To determine whether the diagnosis of polycystic ovary syndrome (PCOS) independently predicts increased rates of pregnancy complications relative to control subjects, after adjusting for important confounders.Design: Retrospective cohort.Setting: Not applicable.Patient(s): A review of all pregnancies after fresh IVF with or without intracytoplasmic sperm injection transfers from December 2006 to 2012 (n = 1,084) identified 394 eligible singleton births (71 women with PCOS; 323 controls without).Intervention(s): Not applicable.Main Outcome Measure(s): Singleton births were assessed for selected adverse pregnancy and birth outcomes.Result(s): Women with PCOS demonstrated a higher risk of developing the following pregnancy complications after adjusting for differences in age, parity, body mass index, and time to conception: gestational diabetes (adjusted odds ratio [AOR] 3.15, 95% confidence interval [CI] 1.35-7.33), hypertensive disorders of pregnancy (AOR 4.25, 95% CI 1.94-9.32), preterm birth 90th percentile (AOR 2.77, 95% CI 1.21-6.35). The increased risk of preterm birth