Tuberculosis and lung cancer
Tuberculosis and lung cancer
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DOI：
10.21149/10090
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发表时间：
2019-06-01
期刊：
影响因子：
--
通讯作者：
Hernández-Pando, Rogelio
中科院分区：
文献类型：
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作者：
Molina-Romero, Camilo;Arrieta, Oscar;Hernández-Pando, Rogelio
目标。介绍肺癌(LC)与肺结核(TB)关系的流行病学研究及其可能的分子机制。材料和方法。我们查阅了研究数据库，搜索包括关键词LC和TB的出版物。结果。已有研究表明，肺结核引起的肺部慢性炎症可引起支气管上皮DNA的断裂活动。另一种可能性是横向基因转移；由于结核分枝杆菌(MTB)是一种细胞内有机体，细菌DNA可以整合到支气管上皮细胞上，诱导肿瘤转化。结论。有流行病学报道，特别是来自亚洲国家的报道，证实了LC和Tb之间的关系。MTb在细胞转化中可能起到积极的作用，阐明其中的机制是重要的。
Objective. To describe the epidemiological studies about the relationship between lung cancer (LC) and pulmonary tuberculosis (Tb) and its possible molecular mechanisms. Materials and methods. We reviewed research databases in search of publications that included keywords LC and Tb. Results. It has been proposed that chronic inflammation in the lungs due to Tb could cause clastogenic activity in the DNA of bronchial epithelium. Another possibility is lateral gene transfer; since Mycobacterium tuberculosis (MTb) is an intracellular organism, bacterial DNA could integrate to bronchial epithelial cells inducing neoplastic transformation. Conclusions. There are epidemiological reports, particularly from Asian countries, which confirm a relationship between LC and Tb.MTb could play an active role in cellular transformation and it is important to elucidate the mechanism involved.