Mitochondrial DNA repair and association with aging--an update.
Mitochondrial DNA repair and association with aging--an update.
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DOI：
10.1016/j.exger.2010.01.017
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发表时间：
2010-08
影响因子：
3.9
通讯作者：
Stevnsner, Tinna
中科院分区：
文献类型：
--
作者：
Gredilla, Ricardo;Bohr, Vilhelm A.;Stevnsner, Tinna
线粒体DNA不断暴露于氧化损伤。由于其位置靠近活性氧的主要位点，线粒体内膜，mtDNA比核DNA更容易受到氧化损伤。DNA损伤的积累被认为在衰老过程中起关键作用，并且在有丝分裂后的细胞中特别有害。因此，DNA修复是维持基因组完整性的重要机制。尽管线粒体在衰老过程中的重要性，但多年来人们一直认为线粒体缺乏与核室中的酶促DNA修复系统相当的酶促DNA修复系统。然而，现在已经确定DNA修复在线粒体中积极发生。氧化性DNA损伤处理，碱基切除修复机制是第一个被描述在这些细胞器，因此最好的理解。然而，新的蛋白质和新的DNA修复途径，被认为只存在于细胞核中，最近被描述也存在于线粒体中。在这里，我们回顾了主要的线粒体DNA修复途径及其与衰老过程的关联。
Mitochondrial DNA is constantly exposed to oxidative injury. Due to its location close to the main site of reactive oxygen species, the inner mitochondrial membrane, mtDNA is more susceptible than nuclear DNA to oxidative damage. The accumulation of DNA damage is thought to play a critical role in the aging process and to be particularly deleterious in post-mitotic cells. Thus, DNA repair is an important mechanism for maintenance of genomic integrity. Despite the importance of mitochondria in the aging process, it was thought for many years that mitochondria lacked an enzymatic DNA repair system comparable to that in the nuclear compartment. However, it is now well established that DNA repair actively takes place in mitochondria. Oxidative DNA damage processing, base excision repair mechanisms were the first to be described in these organelles, and consequently the best understood. However, new proteins and novel DNA repair pathways, thought to be exclusively present in the nucleus, have recently been described also to be present in mitochondria. Here we review the main mitochondrial DNA repair pathways and their association with the aging process.
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影响因子：
14.9
作者：
Chattopadhyay R;Wiederhold L;Szczesny B;Boldogh I;Hazra TK;Izumi T;Mitra S
通讯作者：
Mitra S
影响因子：
5.3
作者：
Brown, Melanie F.;Stuart, Jeffrey A.
通讯作者：
Stuart, Jeffrey A.
DOI：
10.1016/s0027-5107(99)00007-x
发表时间：
1999-03-08
影响因子：
2.3
作者：
Beckman, KB;Ames, BN
通讯作者：
Ames, BN
影响因子：
13.8
作者：
Bohr VA
通讯作者：
Bohr VA
DOI：
10.1006/bbrc.2000.2885
发表时间：
2000-06-24
影响因子：
3.1
作者：
Chang, SW;Zhang, DK;Zassenhaus, HP
通讯作者：
Zassenhaus, HP