IMGT®, the international ImMunoGeneTics information system®
IMGT®, the international ImMunoGeneTics information system®
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DOI：
10.1093/nar/gkn838
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发表时间：
2009-01-01
影响因子：
14.9
通讯作者：
Duroux, Patrice
中科院分区：
文献类型：
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作者：
Lefranc, Marie-Paule;Giudicelli, Veronique;Duroux, Patrice
IMGT (R)，国际免疫遗传学信息系统(R) (http://www.imgt.org)，由法国蒙彼利埃第二大学和法国国家科学研究中心（CNRS）的LIGM免疫遗传学实验室的Marie-Paule Lefranc于1989年创建，目的是标准化和管理复杂的免疫遗传学数据。IMGT- ontology这一独特本体的建立，使IMGT (R)成为免疫遗传学和免疫信息学领域的全球参考。IMGT (R)是一个高质量的综合知识资源，专门研究人类和其他脊椎动物的免疫球蛋白或抗体、T细胞受体、主要组织相容性复合体、IgSF和MhcSF蛋白以及任何物种免疫系统的相关蛋白。IMGT (R)提供了对基因组、蛋白质组、遗传学和3D结构的标准化数据的通用访问。IMGT (R)包括5个数据库（IMGT/LIGM-DB、IMGT/GENE-DB、IMGT/3Dstructure-DB等），15个序列、基因组和3D结构分析的交互式在线工具，以及超过10000个HTML页面的合成和知识。IMGT (R)用于医学研究（自身免疫性疾病、传染病、艾滋病、白血病、淋巴瘤和骨髓瘤）、兽医研究、与抗体工程相关的生物技术（噬菌体展示、组合文库、嵌合抗体、人源化抗体和人类抗体）、诊断（克隆、残留疾病的检测和随访）和治疗方法（移植、免疫治疗、疫苗学）。IMGT可在http://www.imgt.org免费获得。
IMGT (R), the international ImMunoGeneTics information system (R) (http://www.imgt.org), was created in 1989 by Marie-Paule Lefranc, Laboratoire d'ImmunoGenetique Moleculaire LIGM (Universite Montpellier 2 and CNRS) at Montpellier, France, in order to standardize and manage the complexity of immunogenetics data. The building of a unique ontology, IMGT-ONTOLOGY, has made IMGT (R) the global reference in immunogenetics and immunoinformatics. IMGT (R) is a high-quality integrated knowledge resource specialized in the immunoglobulins or antibodies, T cell receptors, major histocompatibility complex, of human and other vertebrate species, proteins of the IgSF and MhcSF, and related proteins of the immune systems of any species. IMGT (R) provides a common access to standardized data from genome, proteome, genetics and 3D structures. IMGT (R) consists of five databases (IMGT/LIGM-DB, IMGT/GENE-DB, IMGT/3Dstructure-DB, etc.), fifteen interactive online tools for sequence, genome and 3D structure analysis, and more than 10 000 HTML pages of synthesis and knowledge. IMGT (R) is used in medical research (autoimmune diseases, infectious diseases, AIDS, leukemias, lymphomas and myelomas), veterinary research, biotechnology related to antibody engineering (phage displays, combinatorial libraries, chimeric, humanized and human antibodies), diagnostics (clonalities, detection and follow-up of residual diseases) and therapeutical approaches (graft, immunotherapy, vaccinology). IMGT is freely available at http://www.imgt.org.