Hard implant coatings with antimicrobial properties
Hard implant coatings with antimicrobial properties
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DOI：
10.1007/s10856-011-4457-6
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发表时间：
2011-12-01
影响因子：
3.7
通讯作者：
Ewald, Andrea
中科院分区：
文献类型：
--
作者：
Moseke, Claus;Gbureck, Uwe;Ewald, Andrea
骨科植入物的感染通常会在术后立即导致炎症，并因重复手术而增加患者的发病率。银离子已显示出联合收割机良好的生物相容性与诱导细菌抗性的低风险相结合。本研究采用电弧沉积和磁控溅射相结合的物理气相沉积系统在钛基体上制备了掺银离子的TiN涂层。该双相体系结合了银诱导结晶性的优点和TiN的良好机械性能。通过X射线衍射的晶体学分析表明，银沉积以及在其元素形式，因为它被纳入到TiN的晶格，这导致增加的TiN涂层的硬度。洗脱实验表明，在磷酸盐缓冲盐水中的银离子的连续释放。该涂层对表皮葡萄球菌和金黄色葡萄球菌的生长有明显的抑制作用，在细胞相容性试验中几乎没有细胞毒性。
Infection of orthopaedic implants often leads to inflammation immediately after surgery and increases patient morbidity due to repetitive operations. Silver ions have been shown to combine good biocompatibility with a low risk of inducing bacterial resistance. In this study a physical vapour deposition system using both arc deposition and magnetron sputtering has been utilized to produce silver ion doped TiN coatings on Ti substrates. This biphasic system combines the advantages of silver induced bactericidity with the good mechanical properties of TiN. Crystallographic analysis by X-ray diffraction showed that silver was deposited as well in its elementary form as it was incorporated into the crystal lattice of TiN, which resulted in increasing hardness of the TiN-coatings. Elution experiments revealed a continuous release of Ag ions in phosphate buffered saline. The coatings showed significant inhibitory effects on the growth of Staphylococcus epidermidis and Staphylococcus aureus and practically no cell-toxicity in cytocompatibility tests.