Digital biomarkers of cognitive function

Digital biomarkers of cognitive function
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DOI:
10.1038/s41746-018-0018-4
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发表时间:
2018-03-28
影响因子:
15.2
通讯作者:
Dagum, Paul
Dagum, Paul
中科院分区:
医学1区
文献类型:
--
作者:
Dagum, Paul

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为了确定与认知功能相关的数字生物标志物,我们分析了27名接受金标准神经心理学评估的受试者(年龄18 - 34岁)7天的智能手机使用过程中的人机交互情况。对于几种神经心理学结构(工作记忆、记忆、执行功能、语言和智力),我们发现了一系列数字生物标志物,它们与测试分数具有高度相关性(p < 10⁻⁴)。这些初步结果表明,智能手机使用的被动测量可以作为基于实验室的神经心理学评估的一种连续的生态替代指标。
To identify digital biomarkers associated with cognitive function, we analyzed human-computer interaction from 7 days of smartphone use in 27 subjects (ages 18-34) who received a gold standard neuropsychological assessment. For several neuropsychological constructs (working memory, memory, executive function, language, and intelligence), we found a family of digital biomarkers that predicted test scores with high correlations (p < 10(-4)). These preliminary results suggest that passive measures from smartphone use could be a continuous ecological surrogate for laboratory-based neuropsychological assessment.