A cluster of the Corona Virus Disease 2019 caused by incubation period transmission in Wuxi, China
A cluster of the Corona Virus Disease 2019 caused by incubation period transmission in Wuxi, China
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DOI：
10.1016/j.jinf.2020.03.042
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发表时间：
2020-06-01
影响因子：
28.2
通讯作者：
Chen, Enping
中科院分区：
文献类型：
--
作者：
Gao, Yumeng;Shi, Chao;Chen, Enping
背景：COVID-2019病例在潜伏期的传染性和传播能力尚不十分清楚。方法：通过“突发公共卫生事件报告管理信息系统”、病例流行病学调查表和实验室资料收集，对该病例进行分析。发病时间分别为发病前2-7天、6- 7天、3-8天、9天。截至3月11日，第四代病例均无症状。结合流行病学资料，我们推断此次聚集性疫情的源头是由第一代人引起的，他们在1月15日至16日年会期间与十余名武汉人接触。结论：确定潜伏期具有传染性，发病前9 d确认具有传染性。出院的患者可能需要观察一段时间。本研究对密切接触者的调查等实际工作具有一定的参考价值。(C)2020作者（S）由Elsevier Ltd代表英国感染协会出版。
Background: The infectivity and transmission capacity of COVID-2019 cases during the incubation period are not very clear. The manuscript described a cluster to provide information for research on incubation period infection.Methods: We collected the required data from "Public Health Emergency Reporting Management Information System", epidemiological questionnaires for the cases, and laboratories.Results: The cluster involved four generations, each of which was transmitted to the next generation during the incubation period. The time was 2-7 days, 6-7days, 3-8 days and 9 days prior to onset. As of March 11, the fourth-generation cases had no symptoms. Combined with the epidemiological data, we inferred that the source of the cluster was caused by the first-generation, who contacted with more than ten Wuhan people during the annual meeting from January 15 to 16. Two cases in this cluster were tested positive again during isolation and observation after discharge.Conclusions: We determined incubation period was infectious, and confirmed that it was contagious 9 days before the onset. The patients who were discharged might need to be observed for a period of time. This study was useful for the practical work, such as in the investigation of close contacts. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association.