Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics
Engineering multi-stage nanovectors for controlled degradation and tunable release kinetics
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DOI：
10.1016/j.biomaterials.2013.07.049
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发表时间：
2013-11-01
期刊：
影响因子：
14
通讯作者：
Tasciotti, Ennio
中科院分区：
文献类型：
--
作者：
Martinez, Jonathan O.;Chiappini, Ciro;Tasciotti, Ennio
纳米载体通过提供一种在靶病变处选择性地积累有效载荷的手段，从而导致治疗指数的增加，从而在减轻治疗剂的脱靶效应方面具有实质性的希望。要实现这些雄心勃勃的目标，就必须对这些纳米载体的降解和释放动力学因素有深入的了解。在这项工作中，我们阐明了存在于孔径变化和多级纳米载体的降解，加载和释放的影响之间的关系。大孔载体显示更快的降解和更高的纳米颗粒负载，同时表现出最慢的释放速率。这些颗粒的降解被表征为以多步骤进展发生，其中它们最初尺寸减小，使多孔芯分离，而孔尺寸逐渐增大。纳米颗粒沿着与扩散建模的经验性加载和释放研究表明，这种延长的释放是由其孔径调节的载体的多孔核内的渗透调制。(C)2013爱思唯尔有限公司保留所有权利。
Nanovectors hold substantial promise in abating the off-target effects of therapeutics by providing a means to selectively accumulate payloads at the target lesion, resulting in an increase in the therapeutic index. A sophisticated understanding of the factors that govern the degradation and release dynamics of these nanovectors is imperative to achieve these ambitious goals. In this work, we elucidate the relationship that exists between variations in pore size and the impact on the degradation, loading, and release of multistage nanovectors. Larger pored vectors displayed faster degradation and higher loading of nanoparticles, while exhibiting the slowest release rate. The degradation of these particles was characterized to occur in a multi-step progression where they initially decreased in size leaving the porous core isolated, while the pores gradually increased in size. Empirical loading and release studies of nanoparticles along with diffusion modeling revealed that this prolonged release was modulated by the penetration within the porous core of the vectors regulated by their pore size. (C) 2013 Elsevier Ltd. All rights reserved.