Narrow-band UVB in the treatment of early stage mycosis fungoides: report of 16 patients
Narrow-band UVB in the treatment of early stage mycosis fungoides: report of 16 patients
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DOI：
10.1111/j.1365-2230.2005.01840.x
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发表时间：
2005-07-01
影响因子：
4.1
通讯作者：
Chams-Davatchi, C
中科院分区：
文献类型：
--
作者：
Ghodsi, SZ;Hallaji, Z;Chams-Davatchi, C
虽然早期蕈样肉芽肿（MF）具有良好的预后，目前的治疗（UVB，光化学疗法，局部氮芥，电子束放疗）的长期生存率是相似的，但人们担心它们的潜在副作用。据报道，同样有效剂量的UVB在致癌性方面比PUVA更安全，而且副作用更少。我们的目的是评估窄带UVB治疗早期ME的效果。16例早期ME患者（7例男性，9例女性;平均年龄40岁）接受TL-01光疗，每周3次，使用标准协议。12例患者（75%）在平均27.9次治疗中完全缓解，3例部分缓解，1例无缓解。停止治疗后，6例完全缓解患者复发，平均复发时间为4.5个月。目前的研究表明，窄谱UVB是一种有效的治疗早期MF的方式。
Although early stage mycosis fungoides (MF) has a generally good prognosis, and long-term survival rates with current therapies (UVB, photochemotherapy, topical nitrogen mustard, electron beam radiotherapy) are similar, there is concern regarding their potential side effects. It has been reported that the same effective UVB dose is safer than PUVA in terms of carcinogenicity, and that it produces fewer side effects. Our aim was to evaluate the effect of narrow-band UVB in the treatment of early stage ME. Sixteen patients (seven males, nine females; mean age, 40 years) with early stage ME received TL-01 phototherapy three times per week using a standard protocol. Twelve patients (75%) had complete response in a mean of 27.9 treatments, three had partial response, and one no response. Upon discontinuation of treatment, six patients with complete response relapsed in a mean time to relapse of 4.5 months. The present study indicates that narrow-band-UVB is an effective treatment modality for early stage MF.