Cutting edge: Acute lung allograft rejection is independent of secondary lymphoid organs.
Cutting edge: Acute lung allograft rejection is independent of secondary lymphoid organs.
复制标题
DOI：
10.4049/jimmunol.0803514
复制
发表时间：
2009-04-01
期刊：
影响因子：
--
通讯作者：
Kreisel D
中科院分区：
文献类型：
--
作者：
Gelman AE;Li W;Richardson SB;Zinselmeyer BH;Lai J;Okazaki M;Kornfeld CG;Kreisel FH;Sugimoto S;Tietjens JR;Dempster J;Patterson GA;Krupnick AS;Miller MJ;Kreisel D
It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung transplantation. We show in this study that alloreactive T cells are initially primed within lung allografts and not in secondary lymphoid organs following transplantation. In contrast to other organs, lungs are acutely rejected in the absence of secondary lymphoid organs. Two-photon microscopy revealed that recipient T cells cluster predominantly around lung-resident, donor-derived CD11c+ cells early after engraftment. These findings demonstrate for the first time that alloimmune responses following lung transplantation are initiated in the graft itself and therefore identify a novel, potentially clinically relevant mechanism of lung allograft rejection.
登录
查看更多内容
DOI：
10.1098/rspb.1958.0058
发表时间：
1958-01-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEDAWAR, PB
通讯作者：
MEDAWAR, PB
DOI：
10.1165/rcmb.2007-0257rc
发表时间：
2007-12-01
影响因子：
6.4
作者：
Okazaki, Mikio;Gelman, Andrew E.;Kreisel, Daniel
通讯作者：
Kreisel, Daniel
影响因子：
8.8
作者：
Zhou, P;Hwang, KW;Alegre, ML
通讯作者：
Alegre, ML
树突状白细胞从心脏同种异体移植到宿主脾脏的迁移。一种新的拒绝途径。
影响因子：
15.3
作者：
LARSEN, CP;MORRIS, PJ;AUSTYN, JM
通讯作者：
AUSTYN, JM
DOI：
10.1073/pnas.092596999
发表时间：
2002-04-30
影响因子：
11.1
作者：
Chalasani, G;Dai, ZH;Lakkis, FG
通讯作者：
Lakkis, FG