A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly
A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly
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DOI：
10.1038/ng.3241
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发表时间：
2015-04-01
期刊：
影响因子：
30.8
通讯作者：
Fujiwara, Haruhiko
中科院分区：
文献类型：
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作者：
Nishikawa, Hideki;Iijima, Takuro;Fujiwara, Haruhiko
在贝叶斯拟态中，动物通过模仿令人讨厌的模型来躲避捕食。在凤尾蝶中，只有拟态的雌性蝴蝶类似于难吃的马兜铃蝶。最近的一份报告显示，单基因，双性（dsx），控制这种模仿(1)；然而，具体的分子机制尚不清楚。在这里，我们确定了两个全基因组序列的P. polytes和一个相关的物种，Papilio xuthus，鉴定了一个相似的130-kb常染色体反转，包括dsx，在P. polytes的模仿（h型）和非模仿（h型）染色体之间。这种倒置与拟态相关的位点H相关联，通过连锁映射确定。敲低实验表明，由倒H等位基因表达的雌性特异性dsx亚型（dsx(H)）诱导模仿的颜色模式，同时抑制非模仿的颜色模式。相反，dsx(h)不会改变模拟模式。我们认为，dsx(H)改变了预定翅膀图案的颜色，而雌性有限的多态性是通过染色体反转紧密维持的。
In Batesian mimicry, animals avoid predation by resembling distasteful models. In the swallowtail butterfly Papilio polytes, only mimetic-form females resemble the unpalatable butterfly Pachliopta aristolochiae. A recent report showed that a single gene, doublesex (dsx), controls this mimicry(1); however, the detailed molecular mechanisms remain unclear. Here we determined two whole-genome sequences of P. polytes and a related species, Papilio xuthus, identifying a single similar to 130-kb autosomal inversion, including dsx, between mimetic (H-type) and non-mimetic (h-type) chromosomes in P. polytes. This inversion is associated with the mimicry-related locus H, as identified by linkage mapping. Knockdown experiments demonstrated that female-specific dsx isoforms expressed from the inverted H allele (dsx(H)) induce mimetic coloration patterns and simultaneously repress non-mimetic patterns. In contrast, dsx(h) does not alter mimetic patterns. We propose that dsx(H) switches the coloration of predetermined wing patterns and that female-limited polymorphism is tightly maintained by chromosomal inversion.