Synthesis of plate-like single-crystal hydroxyapatite rods with c-axis orientation by biotemplate small intestinal submucosa
Synthesis of plate-like single-crystal hydroxyapatite rods with c-axis orientation by biotemplate small intestinal submucosa
复制标题
利用生物模板小肠粘膜下层合成c轴取向板状单晶羟基磷灰石棒
DOI：
10.1016/j.ceramint.2017.06.022
复制
发表时间：
2017-10-15
影响因子：
5.2
通讯作者：
Liu, Xiao
中科院分区：
文献类型：
--
作者：
Bian, Tierong;Zhao, Kang;Liu, Xiao
Since hydroxyapatite crystals are characteristically c-axis orientation on the surface of vertebrate long bone, taxis orientation HAP biomimetic synthesized will find extensive applications in long bone growth, remodeling and fracture healing. In this paper, plate-like single-crystal HAP rods with c-axis orientation was successfully synthesized at bone mineralization conditions in vivo, with small intestinal submucosa membrane as biomineralization template. The samples were characterized by XRD, FIIR, SEM, TEM and EDS to unveil the phase structure, composition, morphology, and a plausible growth mechanism was proposed. The results showed that morphology of samples changed from flower-like to plate-like with extension reaction time from 1 day to 10 days. The plate-like HAp rods were single-crystal with c-axis orientation. A unit of plate-like HAP rods is about 70 mu m and the width is 4 mu m. Phase composition transformed from octocalcium phosphate and HAp biphase to HAp phase with very little octocalcium phosphate phase. Finally, biocompatibility of the samples was evaluated by CCK8. The samples without significant cytotoxicity conformed to the need for substitute materials of bone regeneration.
