Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages
Bacterial [Cu,Zn]-cofactored superoxide dismutase protects opsonized, encapsulated Neisseria meningitidis from phagocytosis by human monocytes/macrophages
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DOI：
10.1128/iai.71.3.1604-1607.2003
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发表时间：
2003-03-01
影响因子：
3.1
通讯作者：
Kroll, JS
中科院分区：
文献类型：
--
作者：
Dunn, KLR;Farrant, JL;Kroll, JS
铜和锌协同作用的超氧化物歧化酶（[Cu，Zn]-SOD）有助于保护调理血清群B脑膜炎奈瑟菌免受人单核细胞/巨噬细胞的吞噬作用，其中sodC突变生物体的内吞数量显著高于野生型生物体。[Cu，Zn]-SOD的影响被认为是在吞噬作用的阶段，而不是在早期（调制表面协会）或后期（细胞内杀伤）阶段。
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup B Neisseria meningitidis against phagocytosis by human monocytes/macrophages, with sodC mutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.