Oxytocin enhances the prolactin response to vasoactive intestinal polypeptide in healthy women
Oxytocin enhances the prolactin response to vasoactive intestinal polypeptide in healthy women
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DOI：
10.1016/s0015-0282(98)00202-7
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发表时间：
1998-09-01
影响因子：
6.7
通讯作者：
Coiro, V
中科院分区：
文献类型：
--
作者：
Chiodera, P;Volpi, R;Coiro, V
目的：探讨催产素是否能改变血管活性肠多肽（VIP）对健康女性泌乳素分泌的刺激作用。设计：对照临床研究。环境：健康女性在学术研究环境中。患者：7名健康女性（24-32岁）在连续两个正常月经周期的第22天进行检测。干预措施：血管活性肠多肽（4 pmol）。公斤(1)。在有或没有催产素同时治疗的情况下（注射2 IU + 0.07 IU/min，注射60分钟），给予50ml生理盐水min（-1）。主要观察指标：血清催乳素水平。结果：注射VIP后血清催乳素水平显著升高，注射后45分钟的平均峰值反应比基线高1.6倍。在催产素存在的情况下，泌乳素对VIP的反应明显更高，平均峰值反应比基线高2倍。结论：在健康女性中，催产素有助于调节VIP对催乳素分泌的刺激作用。[j] .中国农业科学（英文版）1998;37(1):1-3。(C) 1998年由美国生殖医学学会出版。
Objective: To establish whether oxytocin modifies the stimulatory effect of vasoactive intestinal polypeptide (VIP) on prolactin secretion in healthy women.Design: Controlled clinical study.Setting: Healthy women in an academic research environment.Patient(s): Seven healthy women (aged 24-32 years) were tested on the 22nd day of two consecutive normal menstrual cycles.Intervention(s): Vasoactive intestinal polypeptide (4 pmol . kg(-1) . min(-1) in 50 mL of normal saline infused IV for 60 minutes) was administered in either the presence or absence of concurrent treatment with oxytocin (2 IU injected plus 0.07 IU/min infused for 60 minutes).Main Outcome Measure(s): Serum prolactin levels.Result(s): The administration of VIP induced a significant increase in serum prolactin levels, with a mean peak response 1.6 times higher than baseline at 45 minutes after injection. Tn the presence of oxytocin, the prolactin response to VIP was significantly higher, with a mean peak response 2 times higher than baseline.Conclusion(s): These data suggest that in healthy women, oxytocin facilitates the regulation of the stimulating effect of VIP on prolactin secretion. (Fertil Steril(R) 1998;70:541-3. (C) 1998 by American Society for Reproductive Medicine.).