Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates.
Fabrication of calcium phosphate microcapsules using emulsion droplets stabilized with branched copolymers as templates.
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DOI：
10.1039/c5tb00893j
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发表时间：
2015-07
期刊：
影响因子：
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通讯作者：
Robert V. Bell;L. Rochford;R. T. D. de Rosales;M. Stevens;J. Weaver;S. Bon
中科院分区：
文献类型：
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作者：
Robert V. Bell;L. Rochford;R. T. D. de Rosales;M. Stevens;J. Weaver;S. Bon
我们报道了一种多功能和时间有效的方法来制造磷酸钙（CaP）微胶囊，利用合成支化共聚物（BCP）作为模板稳定的水包油乳液液滴。BCP被设计为提供合适的结构和功能以产生稳定的乳液液滴，并且当在含有钙和磷酸根离子的溶液中孵育时允许CaP在油滴表面矿化。微胶囊的CaP壳被确定为具有掺入的氯和碳酸盐物种的缺钙羟基磷灰石。这些囊壁通过用荧光素-双膦酸酯缀合物装饰而发出荧光。
We report on a versatile and time-efficient method to fabricate calcium phosphate (CaP) microcapsules by utilizing oil-in-water emulsion droplets stabilized with synthetic branched copolymer (BCP) as templates. The BCP was designed to provide a suitable architecture and functionality to produce stable emulsion droplets, and to permit the mineralization of CaP at the surface of the oil droplet when incubated in a solution containing calcium and phosphate ions. The CaP shells of the microcapsules were established to be calcium deficient hydroxyapatite with incorporated chlorine and carbonate species. These capsule walls were made fluorescent by decoration with a fluorescein-bisphosphonate conjugate.