Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice
Stimulus dynamics-dependent information transfer of olfactory and vomeronasal sensory neurons in mice
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DOI：
10.1016/j.neuroscience.2018.12.043
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发表时间：
2019-02-21
期刊：
影响因子：
3.3
通讯作者：
Kashiwayanagi, Makoto
中科院分区：
文献类型：
--
作者：
Noguchi, Tomohiro;Miyazono, Sadaharu;Kashiwayanagi, Makoto
已知主要嗅觉系统和犁鼻系统对化学信号的平行处理控制动物行为。由嗅感觉神经元和犁鼻感觉神经元组成的外周平行通路的生理意义还不清楚。在这里，我们展示了嗅觉感觉神经元和犁鼻感觉神经元的信息传递的互补特征。通过膜片钳实验发现感觉神经元之间的兴奋性存在差异。嗅觉和犁鼻感觉神经元分别表现出阶段性和强直性放电。固有通道动力学确定的放电模式证明了霍奇金-赫胥黎式的计算。我们的估计的信息进行的正弦刺激周期与可变的持续时间在一个周期的动作电位揭示了不同的特征的感觉神经元之间的信息传递。嗅觉感觉神经元的时相放电适合于在较短的周期（500 ms）内传递快速变化的信息。因此，这两种类型的感觉神经元的平行通路可以传递关于广泛的动态刺激的信息。嗅觉信息传递的互补特征的组合可能增强主嗅觉系统和犁鼻系统之间的相互作用的协同作用。(C)2018年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The parallel processing of chemical signals by the main olfactory system and the vomeronasal system has been known to control animal behavior. The physiological significance of peripheral parallel pathways consisting of olfactory sensory neurons and vomeronasal sensory neurons is not well understood. Here, we show complementary characteristics of the information transfer of the olfactory sensory neurons and vomeronasal sensory neurons. A difference in excitability between the sensory neurons was revealed by patch-clamp experiments. The olfactory and vomeronasal sensory neurons showed phasic and tonic firing, respectively. Intrinsic channel kinetics determining firing patterns was demonstrated by a Hodgkin-Huxley-style computation. Our estimation of the information carried by action potentials during one cycle of sinusoidal stimulation with variable durations revealed distinct characteristics of information transfer between the sensory neurons. Phasic firing of the olfactory sensory neurons was suitable to carry information about rapid changes in a shorter cycle (500 ms). Thus, the parallel pathways of the two types of sensory neurons can convey information about a wide range of dynamic stimuli. A combination of complementary characteristics of olfactory information transfer may enhance the synergy of the interaction between the main olfactory system and the vomeronasal system. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.