Adjuvant Radiation Therapy of Retroperitoneal Sarcoma: The Role of Intraoperative Radiotherapy (IORT).
Adjuvant Radiation Therapy of Retroperitoneal Sarcoma: The Role of Intraoperative Radiotherapy (IORT).
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DOI：
10.1155/s1357714x00000037
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发表时间：
2000-01-01
期刊：
影响因子：
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通讯作者：
Harrison, L C
中科院分区：
文献类型：
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作者：
Hu, K S;Harrison, L C
目的。目的是回顾自然史、临床病理预后因素和辅助放射治疗的作用，特别关注 IORT 的有限但有利的经验。方法。腹膜后肉瘤对肿瘤学家提出了持续的治疗挑战。与四肢和浅表躯干肉瘤完全切除加放射治疗可实现良好的局部控制相比，腹膜后肉瘤难以切除，即使完全切除，局部复发率也很高，这是失败的主要模式。由于邻近正常器官，辅助外束放射治疗的治疗剂量的输送存在问题。向大多数患者输送足够剂量（>60 Gy）的外束将导致不可接受的毒性。治疗困境是不幸的，需要更好的策略。一种有吸引力的方法是将术中放射治疗 (IORT) 与最大切除和外照射结合起来。结果和讨论。许多机构已经探索了这种方法，并取得了令人鼓舞的初步结果。
Purpose. The purpose is to review the natural history, the clinicopathological prognostic factors, and the role of adjuvant radiation therapy with particular attention to the limited but favorable experience with IORT.Methods. Retroperitoneal sarcomas present a continuing therapeutic challenge to the oncologist. In contrast to sarcomas of the extremity and superficial trunk in which complete resection plus radiation therapy results in excellent local control, sarcomas of the retroperitoneum are difficult to resect and even if completely resected, demonstrate high rates of local relapse, the primary pattern of failure. Due to the proximity of normal organs, the delivery of therapeutic doses of adjuvant external beam radiation therapy is problematic.To deliver adequate doses (>60 Gy) of external beam to most patients would result in unacceptable toxicity. The therapeutic dilemma is unfortunate and better strategies are needed. One attractive approach has been to incorporate intraoperative radiation therapy (IORT) with maximal resection and external beam radiation. Results and Discussion. A number of institutions have explored this approach with encouraging preliminary results.