Receptor Dynamics in Signaling
Receptor Dynamics in Signaling
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DOI：
10.1007/978-1-4419-7210-1_18
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
Klingmueller, Ursula
中科院分区：
文献类型：
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作者：
Becker, Verena;Timmer, Jens;Klingmueller, Ursula
可靠的细胞间和细胞内通讯是多细胞生物体发育和完整性的核心。这些过程的关键介质是细胞表面受体，其感知并转换细胞外信号以触发细胞内信号网络并最终触发表型反应。信号转导的失调导致多种疾病，并且受体蛋白的畸变在各种癌症类型中非常常见。因此，细胞表面受体已被确立为药物发现的主要靶点。然而，为了有效地应用治疗方法，获得有关受体信号传导的设计原理的知识至关重要。在本章中，我们将讨论信号转导在受体水平的例子从不同的受体类。
Reliable inter- and intracellular communication is central to both the development and the integrity of multicellular organisms. Key mediators of these processes are cell surface receptors that perceive and convert extracellular cues to trigger intracellular signaling networks and ultimately a phenotypic response. Deregulation of signal transduction leads to a variety of diseases, and aberrations in receptor proteins are very common in various cancer types. Therefore, cell surface receptors have been established as major targets in drug discovery. However, in order to efficiently apply therapeutics, it is crucial to gain knowledge about design principles of receptor signaling. In this chapter, we will discuss signal transduction at the receptor level for examples from different receptor classes.