COLORECTAL-CANCER IN ULCERATIVE-COLITIS - INFLUENCE OF ANATOMICAL EXTENT AND AGE AT ONSET ON COLITIS-CANCER INTERVAL
COLORECTAL-CANCER IN ULCERATIVE-COLITIS - INFLUENCE OF ANATOMICAL EXTENT AND AGE AT ONSET ON COLITIS-CANCER INTERVAL
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DOI：
10.1136/gut.32.2.167
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发表时间：
1991-02-01
期刊：
影响因子：
24.5
通讯作者：
GREENSTEIN, AJ
中科院分区：
文献类型：
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作者：
SUGITA, A;SACHAR, DB;GREENSTEIN, AJ
我们检查了 1959 年至 1988 年间在西奈山医院就诊的 100 名患者的溃疡性结肠炎和结肠炎相关结直肠癌的发病年龄。其中 85 名患者患有广泛性结肠炎，15 名患者患有左侧结肠炎。溃疡性结肠炎发病年龄与癌症诊断年龄之间存在很强的直接相关性（p < 0.0001）；这种相关性在广泛性结肠炎患者 (p < 0.0001) 和左侧结肠炎患者 (p < 0.005) 中均存在。患有左侧结肠炎的患者比那些患有广泛疾病的患者晚大约十年左右才出现结肠炎和癌症，但无论发病年龄如何，两组在诊断出癌症之前结肠炎的平均持续时间实际上相同（约 21 年）。
We have examined the age at onset of both ulcerative colitis and colitis-associated colorectal cancer in 100 patients seen at Mount Sinai Hospital between 1959 and 1988. There were 85 patients with extensive colitis and 15 with left sided colitis. There was a strong direct correlation between the age at onset of ulcerative colitis and age at diagnosis of cancer (p < 0.0001); this correlation was found both in patients with extensive colitis (p < 0.0001) and in those with left sided colitis (p < 0.005). Patients with left sided colitis developed both their colitis and their cancers about a decade later than did those with extensive disease, but the mean duration of colitis before diagnosis of cancer was virtually the same (about 21 years) in both groups, irrespective of the age at onset of disease.