Variability of cutaneous lymphatic flow rates in melanoma patients
Variability of cutaneous lymphatic flow rates in melanoma patients
复制标题
黑色素瘤患者皮肤淋巴流速的变异性
DOI：
10.1097/00008390-199806000-00012
复制
发表时间：
1998
影响因子：
2.2
通讯作者：
E. Bernard
中科院分区：
文献类型：
--
作者：
R. Uren;R. Howman;J. Thompson;J. Roberts;E. Bernard
连续198例皮肤黑色素瘤患者在手术治疗前进行了淋巴核素扫描。皮内注射~(99m)Tm标记的硫化锑胶体后，测量每个患者的淋巴流率，发现淋巴流速随原发肿瘤的位置而异。最快的血流速度发生在四肢远端的黑色素瘤部位，尤其是下肢。血流速度最慢的部位是头颈部和四肢近端，尤其是上臂和肩部。早期动态图像中血流不足最常见于上臂和肩部肿瘤。这些结果可用于优化手术前注射蓝色染料的时机，并可能影响前哨淋巴结活检方法用于未显示早期引流的个体。
Preoperative lymphoscintigraphy was performed in 198 consecutive patients with cutaneous melanoma prior to their definitive surgical treatment. After intradermal injection of antimony sulphide colloid labelled with technetium- 99m, lymphatic flow rates were measured in each patient and found to vary according to the location of the primary tumour. The fastest flow rates occurred from melanoma sites on the distal limbs, particularly the lower limbs. The slowest flow rates were from the head and neck region and the proximal limbs, especially the upper arms and shoulders. Lack of flow in the early dynamic images occurred most commonly for tumours on the upper arms and shoulders. These results can be used to optimize the timing of blue dye injection prior to surgery and may influence the sentinel node biopsy method to be used in individuals who show no early drainage.