Effect of successful weight loss program on biomarkers for breast cancer in postmenopausal high-risk women.
Effect of successful weight loss program on biomarkers for breast cancer in postmenopausal high-risk women.
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成功的减肥计划对绝经后高危女性乳腺癌生物标志物的影响。
DOI：
10.1200/jco.2010.28.15_suppl.1522
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发表时间：
2010
影响因子：
45.3
通讯作者：
Henry Yeh
中科院分区：
文献类型：
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作者：
C. Fabian;J. Klemp;B. Kimler;Sonya Aversman;T. Phillips;C. Zalles;D. Sullivan;B. Smith;J. Donnelly;Henry Yeh
1522背景：超重女性降低乳腺癌风险所需的基线体重或脂肪减少比例尚未确定。我们进行了一项初步研究，以确定有组织的减肥计划对血清和组织乳腺癌风险生物标志物的影响。方法：绝经后未接受HRT的BMI为bbb25 kg/m2的妇女，如果她们符合5年Gail bbb_1 1.7%、既往对侧乳腺癌或癌前活检的风险标准；随机乳晕周围细针穿刺（RPFNA）采集乳腺组织，显示增生证据，Ki-67 > 1.5%。我们的主要终点是确定体重减轻≥5%的女性比例及其对Ki-67的影响。由于Ki-67的女性比例低，最低资格标准改为细胞形态学和冷冻同源物。我们为期6个月的减肥干预包括减少能量饮食、体育锻炼和每周与其他高危妇女开会讨论行为策略。身体成分（DEXA），禁食…
1522 Background: The proportion of baseline weight or fat loss needed for breast cancer risk reduction in overweight women is not defined. We conducted a pilot study to determine the effect of a structured weight loss program on serum and tissue breast cancer risk biomarkers. Methods: Postmenopausal women with BMI > 25 kg/m2 not on HRT were eligible if they met risk criteria of 5-yr Gail > 1.7%, prior contra- lateral breast cancer, or precancerous biopsy; and had breast tissue harvested by random periareolar fine needle aspiration (RPFNA) indicating evidence of hyperplasia and Ki-67 > 1.5%. Our primary endpoint was to determine the proportion of women with ≥ 5% weight loss and effect on Ki-67. Due to low proportion of women with Ki-67, minimum eligibility criteria were changed to cytomorphology and a frozen aliquot. Our 6-month weight loss intervention included reduced energy diet, physical activity, and weekly meetings for behavioral strategies with other high risk women. Body composition (DEXA), fasting...