A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women
A 3-day estrogen treatment improves prefrontal cortex-dependent cognitive function in postmenopausal women
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DOI：
10.1016/j.psyneuen.2006.05.007
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发表时间：
2006-09-01
影响因子：
3.7
通讯作者：
Rasch, Bjoern
中科院分区：
文献类型：
--
作者：
Krug, Rosemarie;Born, Jan;Rasch, Bjoern
年轻女性的雌激素分泌遵循一种周期性模式，其特征是排卵前后雌激素明显激增。这种雌激素峰值影响认知功能的方式尚不清楚。模拟正常绝经前雌激素动力学的短期雌激素治疗几天大大增强了卵巢切除动物的认知功能。在这里，我们提供的证据表明，诱导绝经后妇女的一个单一的雌激素峰值，提高他们的认知能力。健康女性（51- 64岁，n = 14）在一个双盲的受试者内设计中接受100 μ g雌激素透皮给药3天或安慰剂。治疗引起血清雌激素水平暂时上升，大致相当于年轻女性雌激素的中期周期变化。在治疗结束时，女性完成了两种类型的测试，主要涉及记忆保留的大脑皮层依赖功能或前额叶皮层依赖功能。结果显示，雌激素对主要涉及前额叶皮层的任务有明显的有益影响：在数字排序任务（p < 0.05）和需要对不熟悉故事中的事件序列进行短期记忆的任务（p < 0.01）上的表现得到改善，雌激素后Stroop测试中对干扰的敏感性（p < 0.05）降低。另一方面，雌激素并不影响记忆依赖性的故事保留，延迟回忆测试后30分钟或1周，虽然即时回忆改善了雌激素。我们的结论是，在绝经后妇女，血浆雌激素浓度的短暂增加，急性改善前额叶皮质依赖的认知功能，而海马依赖的记忆保留是受影响较小。我们的研究结果鼓励未来的研究，以调查是否重复诱导的短期雌激素峰值可以提高认知疗效的激素替代疗法。(c)2006爱思唯尔有限公司保留所有权利。
Estrogen secretion in young women follows a cyclic pattern characterized by a pronounced surge in estrogen around ovulation. The way in which this estrogen peak affects cognitive functioning is unclear. Short-term estrogen treatment for a few days mimicking normal pre-menopausal estrogen dynamics substantially enhanced cognitive functions in ovariectomized animals. Here, we provide evidence that inducing a single estrogen peak in postmenopausal women improves their cognitive abilities. Healthy women (51-64yrs, n = 14) received either 100 mu g estrogen transdermally for 3 days or placebo in a double-blind within-subject design. The treatment caused a temporary rise in serum estrogen levels roughly comparable to the mid-cyclic changes in estrogen in young women. At the end of the treatment, the women completed two types of tests involving primarily hippocampus-dependent functions of memory retention or prefrontal cortex-dependent functions. Results revealed a clear beneficial effect of estrogen on tasks mainly involving the prefrontal cortex: performance on a digit-ordering task (p < 0.05) and on a task requiring short-term memory of event sequences in an unfamiliar story (p < 0.01) were improved, and susceptibility to interference in the Stroop test (p < 0.05) was diminished after estrogen. On the other hand, estrogen did not affect hippocampus-dependent retention of a story, with delayed recall tested after 30 min or 1 week, although immediate recall was improved by estrogen. We conclude that in postmenopausal women, a transient increase in plasma estrogen concentration acutely improves prefrontal cortex-dependent cognitive functions, whereas hippocampus-dependent memory retention is Less affected. Our results encourage future studies to investigate whether repeated induction of short-lasting estrogen peaks could enhance cognitive efficacy of hormonal replacement therapy. (c) 2006 Elsevier Ltd. All rights reserved.