A role for neuropeptide Y (NPY) in phagocytosis:: Implications for innate and adaptive immunity
A role for neuropeptide Y (NPY) in phagocytosis:: Implications for innate and adaptive immunity
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DOI：
10.1016/j.peptides.2006.07.029
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发表时间：
2007-02-01
期刊：
影响因子：
3
通讯作者：
Gebhardt, Thomas
中科院分区：
文献类型：
--
作者：
Bedoui, Sammy;von Hoersten, Stephan;Gebhardt, Thomas
尽管人们普遍认为免疫系统和神经系统在各个层面上相互作用，但这种相互作用的许多方面仍不清楚。这种相互作用中的一个参与者是神经肽Y (NPY)，一种交感神经递质，已被证明可以调节多种免疫功能。在这篇综述中，我们将概述NPY对中性粒细胞和单核/巨噬细胞吞噬作用的影响及其与消除入侵病原体的相关性的主要发现。此外，我们将讨论这些发现对树突状细胞抗原呈递和诱导适应性免疫反应的意义。(c) 2007爱思唯尔公司版权所有。
Although it is broadly accepted that the immune system and the nervous system functionally interact with each other at various levels, many aspects of this crosstalk still remain unclear. One player in this interaction is neuropeptide Y (NPY), a sympathetic neurotransmitter, which has been demonstrated to regulate a broad variety of immune functions. in this review we will outline key findings on the effects NPY exerts on phagocytosis by neutrophils and monocytes/macrophages and its relevance to the elimination of invading pathogens. Furthermore, we will discuss the implications of these findings for antigen presentation by dendritic cells and the induction of adaptive immune responses. (c) 2007 Elsevier Inc. All rights reserved.