CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient
CD20-Negative CD138-Positive Leukemic Large Cell Lymphoma with Plasmablastic Differentiation with an IgH/MYC Translocation in an HIV-Positive Patient
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DOI：
10.2169/internalmedicine.48.1359
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发表时间：
2009-01-01
影响因子：
1.2
通讯作者：
Kobayashi, Hikaru
中科院分区：
文献类型：
--
作者：
Yotsumoto, Mihoko;Ichikawa, Naoaki;Kobayashi, Hikaru
一名49岁hiv阳性日本男子因多发皮肤结节转诊至我院。外周血中可见大量浆质性非典型淋巴细胞。他被诊断为弥漫性大B细胞淋巴瘤（DLBCL）腹股沟淋巴结活检。淋巴结原位杂交检测IgH/MYC易位，骨髓细胞染色体分析显示46，XY, t(8; 14)(q24; q32) add(14)(q32), der(21) t(1; 21)（q12; p11）。他对多药化疗有短暂反应，在补救性化疗过程中，他死于尿路感染。与先前报道的质母细胞分化的dlbcl相比，该病例具有独特的临床特征。
A 49-year-old HIV-positive Japanese man was referred to our hospital for multiple skin nodules. Many plasmablastic atypical lymphocytes were observed in the peripheral blood. He was diagnosed with diffuse large B cell lymphoma (DLBCL) by a biopsy of the inguinal lymph node. IgH/MYC translocation was detected by in situ hybridization of the lymph node and chromosomal analysis of bone marrow cells showed 46, XY, t(8; 14)(q24; q32) add(14)(q32), der(21) t(1; 21)(q12; p11). He showed a transient response to multi-agent chemotherapy, and during the course of salvage chemotherapy, he died of urinary infection. This case has unique clinical features compared with previously reported DLBCLs with plasmablastic differentiation.