LOW-FREQUENCY RESPIRATORY MECHANICAL IMPEDANCE IN THE RAT
LOW-FREQUENCY RESPIRATORY MECHANICAL IMPEDANCE IN THE RAT
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DOI：
10.1152/jappl.1987.63.1.36
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发表时间：
1987-07-01
影响因子：
3.3
通讯作者：
NAGY, S
中科院分区：
文献类型：
--
作者：
HANTOS, Z;DAROCZY, B;NAGY, S
一种改进的强迫振荡技术被用来确定呼吸机械阻抗在麻醉，瘫痪大鼠之间的0.25和10赫兹。根据分别在开胸手术前后在气道开口处施加伪随机振荡测量的总呼吸阻抗（Zrs）和肺阻抗（ZL），胸壁阻抗（Zw）计算为Zw = Zrs-ZL。肺（RL）和胸壁阻力都是明显的频率依赖性的：在0.25和2 Hz之间，它们对总阻力的贡献相等，从81.4 ± 0.5 Hz下降。18.3（SD）在0.25 Hz至27.1 . ±. 1.7 kPa. cntdot. l-1. cntdot.在2 Hz。肺顺应性（CL）轻度降低，从2.78 ±。0.44在0.25 Hz至2.36 . ±. 0.39 ml/kPa，然后在更高的频率下增加，而胸壁顺应性从4.19 ± 0.01单调下降。0.88在0.25 Hz至1.93 . ±. 0.14 ml/kPa。虽然Zw的频率依赖性可以解释的基础上，单独的平行不均匀性，在RL的急剧下降连同相对恒定的CL表明，在低频率下，显着的损失是由肺组织的非牛顿电阻特性。
A modified forced oscillatory technique was used to determine the respiratory mechanical impedances in anesthetized, paralyzed rats between 0.25 and 10 Hz. From the total respiratory (Zrs) and pulmonary impedance (ZL), measured with pseudorandom oscillations applied at the airway opening before and after thoracotomy, respectively, the chest wall impedance (Zw) was calculated as Zw = Zrs - ZL. The pulmonary (RL) and chest wall resistances were both markedly frequency dependent: between 0.25 and 2 Hz they contributed equally to the total resistance falling from 81.4 .+-. 18.3 (SD) at 0.25 Hz to 27.1 .+-. 1.7 kPa .cntdot. l-1 .cntdot. s at 2 Hz. The pulmonary compliance (CL) decreased mildly, from 2.78 .+-. 0.44 at 0.25 Hz to 2.36 .+-. 0.39 ml/kPa at 2 Hz, and then increased at higher frequencies, whereas the chest wall compliance declined monotonously from 4.19 .+-. 0.88 at 0.25 Hz to 1.93 .+-. 0.14 ml/kPa at 10 Hz. Although the frequency dependence of Zw can be interpreted on the basis of parallel inhomogeneities alone, the sharp fall in RL together with the relatively constant CL suggests that at low frequencies significant losses are imposed by the non-Newtonian resistive properties of the lung tissue.