Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
Effects of L-DOPA on neuronal activity of the globus pallidus externalis (GPe) and globus pallidus internalis (GPi) in the MPTP-treated monkey
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DOI：
10.1016/s0006-8993(97)01563-1
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发表时间：
1998-03-16
期刊：
影响因子：
2.9
通讯作者：
Gross, C
中科院分区：
文献类型：
--
作者：
Boraud, T;Bezard, E;Gross, C
我们研究了L多巴对实验性帕金森病苍白球神经元放电模式的影响。在单侧注射MPTP后，我们观察到GPE神经元的放电频率降低，其爆发性活动略有增加。在GPI，神经元的放电频率和爆裂细胞的数量都有显著的增加。在L多巴(10 mg/kg)治疗期间，GPE神经元的形态几乎没有改变。相反，GPI神经元的放电频率降低，甚至低于对照组水平。观察到爆发活动略有减少。这些意想不到的结果将表明，L-DOPA对GPI产出的归一化效应有限。(C)1998年爱思唯尔科学公司。
We studied the effects of L-DOPA on the firing patterns of pallidal neurons in experimental parkinsonism. After a unilateral injection of MPTP, we observed a decrease in the firing rate of GPe neurons, and a slight increase in their bursting activity. In the GPI, there was a considerable augmentation of both neuronal firing frequency and the number of bursting cells. During L-DOPA treatment (10 mg/kg), GPe neurons.pattern is almost unmodified. The firing frequency of GPi neurons, on the contrary, decreased even lower than the control level. A slight reduction was observed in bursting activity. These unexpected results would show that the normalizing effect of L-DOPA on GPi output is limited. (C) 1998 Elsevier Science B.V.