Molecular Systems Biology Peer Review Process File Construction of Human Activity-based Phosphorylation Networks Transaction Report-猫眼课题宝

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R. Newman;Jianfei Hu;Hee-Sool Rho;Zhi Xie;Crystal L. Woodard;J. Neiswinger;Christopher Cooper;

(注：除更正可能引起歧义的排字或拼写错误外，信件和报告不作编辑。信件和推荐人报告的原始格式可能不会反映在本汇编中。)再次感谢您将您的工作提交给分子系统生物学。我们现在已经收到了四位裁判的回复，他们同意评估你的手稿。正如你将从下面的报道中看到的那样，裁判，特别是最后三名裁判，都谨慎地表示支持。然而，它们引起了很大的关注，我恐怕这必须阻止它以目前的形式发表。评审员提供了详细的报告，提出了一系列重要的技术和概念问题，在这项工作被接受发表在分子系统生物学之前，需要令人信服地解决这些问题。我在这里强调其中的几个问题：1.不止一位评审员对提交的凝胶数据的质量有问题，第二位评审员认为需要清楚地证明这些结果的重复性。可能需要更多的实验和重复分析来解决这些问题。在这种情况下，我们还要求您提供这项工作中展示的所有凝胶的原始未经处理的凝胶图像作为补充材料，以符合我们关于数据发布和科学透明度的政策。请将未处理/未裁剪的凝胶图像作为单独的文件包含在单个压缩文件夹中，并上传这是一个补充数据集。如果可用，还应包括复制凝胶。文件名应该清楚地将凝胶链接到适当的图形面板。2.研究人员发现，依赖磷酸化的蛋白质稳定性在一定程度上发生了变化

(Note: With the exception of the correction of typographical or spelling errors that could be a source of ambiguity, letters and reports are not edited. The original formatting of letters and referee reports may not be reflected in this compilation.) Thank you again for submitting your work to Molecular Systems Biology. We have now heard back from the four referees who agreed to evaluate your manuscript. As you will see from the reports below, the referees, particularly the last three, were cautiously supportive. They raised, however, substantial concerns, which, I am afraid to say, must preclude its publication in its present form. The reviewers provided detailed reports that raise a series of important technical and conceptual issues that will need to be convincingly addressed before this work would be acceptable for publication at Molecular Systems Biology. I highlight a few of these issues here: 1. More than one reviewer had issues with the quality of the presented gel data, and Reviewer #2 felt that the reproducibility of these results would need to be clearly demonstrated. Additional experiments and replicate analyses may be needed to address these concerns. In this case, we also ask that you provide the original unprocessed gel images for all gels presented in this work as supplemental material, in line with our policies on data release and scientific transparency. Please include the unprocessed/uncropped gel images as individual files within a single zip folder, and upload this is a supplemental dataset. Replicate gels should also be included when available. File names should clearly link the gels to the appropriate figure panels. 2. The reviewers found the phosphorylation-dependent changes in protein stability somewhat

Molecular Systems Biology Peer Review Process File Construction of Human Activity-based Phosphorylation Networks Transaction Report

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