ChAdOx1 nCoV-19 vaccination generates spike-specific CD8+ T cells in aged mice.
ChAdOx1 nCoV-19 vaccination generates spike-specific CD8+ T cells in aged mice.
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ChAdOx1 nCoV-19 疫苗接种可在老年小鼠中产生尖峰特异性 CD8 T 细胞。
DOI：
10.1111/imcb.12645
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发表时间：
2023
影响因子：
4
通讯作者：
Foster WS
中科院分区：
文献类型：
--
作者：
Foster WS
有效的疫苗降低了严重急性呼吸综合征冠状病毒- 2感染引起的发病率和死亡率；然而，老年人仍然是风险最大的人群。了解疫苗如何产生保护性免疫以及这些机制如何随年龄变化是为未来疫苗设计提供信息的关键。细胞毒性CD8+T细胞对于杀死病毒感染的细胞是重要的，而除了体液免疫外，诱导抗原特异性CD8+T细胞的疫苗提供了额外的免疫保护层。这在抗体滴度不理想的情况下尤其重要，如在老年人中可能发生的情况。本研究表明，在老年小鼠中，接种ChAdOx1 nCoV‐19疫苗后，刺突表位特异性CD8+T细胞的产生数量与年轻小鼠相当，尽管存在表型差异。这表明ChAdOx1 nCoV - 19在老年人体内引起良好的CD8+T细胞反应，但典型的年龄相关特征在这些疫苗反应性T细胞上很明显。
Effective vaccines have reduced the morbidity and mortality caused by severe acute respiratory syndrome coronavirus‐2 infection; however, the elderly remain the most at risk. Understanding how vaccines generate protective immunity and how these mechanisms change with age is key for informing future vaccine design. Cytotoxic CD8+T cells are important for killing virally infected cells, and vaccines that induce antigen‐specific CD8+T cells in addition to humoral immunity provide an extra layer of immune protection. This is particularly important in cases where antibody titers are suboptimal, as can occur in older individuals. Here, we show that in aged mice, spike epitope–specific CD8+T cells are generated in comparable numbers to younger animals after ChAdOx1 nCoV‐19 vaccination, although phenotypic differences exist. This demonstrates that ChAdOx1 nCoV‐19 elicits a good CD8+T‐cell response in older bodies, but that typical age‐associated features are evident on these vaccine reactive T cells.