Alveologenesis: key cellular players and fibroblast growth factor 10 signaling.
Alveologenesis: key cellular players and fibroblast growth factor 10 signaling.
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DOI：
10.1186/s40348-016-0045-7
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Bellusci S
中科院分区：
文献类型：
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作者：
Chao CM;Moiseenko A;Zimmer KP;Bellusci S
肺泡发生是肺发育的最后阶段，对于建立称为肺泡的气体交换单位至关重要。尽管深入的肺部研究，肺泡形成过程中间充质和上皮细胞谱系之间的复杂串扰知之甚少。这种串扰有助于次级隔膜的形成，次级隔膜是健康肺泡的关键结构。更好地了解次级隔膜形成的细胞和分子过程对于开发保护或再生肺泡的新疗法至关重要。本文就小鼠和人肺泡发生的过程作一简要综述。此外，它讨论了目前对早期肺发育过程中上皮和间充质祖细胞的认识，这些细胞引起了关键的细胞参与者（例如，I型肺泡上皮细胞、II型肺泡上皮细胞、肺泡肌成纤维细胞、脂成纤维细胞）。这篇综述主要集中在成纤维细胞生长因子10（FGF10），肺发育过程中最重要的信号分子之一，在上皮细胞和间充质细胞谱系形成的作用。
Alveologenesis is the last stage in lung development and is essential for building the gas-exchanging units called alveoli. Despite intensive lung research, the intricate crosstalk between mesenchymal and epithelial cell lineages during alveologenesis is poorly understood. This crosstalk contributes to the formation of the secondary septae, which are key structures of healthy alveoli. A better understanding of the cellular and molecular processes underlying the formation of the secondary septae is critical for the development of new therapies to protect or regenerate the alveoli. This review summarizes briefly the alveologenesis process in mouse and human. Further, it discusses the current knowledge on the epithelial and mesenchymal progenitor cells during early lung development giving rise to the key cellular players (e.g., alveolar epithelial cell type I, alveolar epithelial cell type II, alveolar myofibroblast, lipofibroblast) involved in alveologenesis. This review focusses mainly on the role of fibroblast growth factor 10 (FGF10), one of the most important signaling molecules during lung development, in epithelial and mesenchymal cell lineage formation.