Choroidal Thickness in Geographic Atrophy Secondary to Age-Related Macular Degeneration
Choroidal Thickness in Geographic Atrophy Secondary to Age-Related Macular Degeneration
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DOI：
10.1167/iovs.14-14933
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发表时间：
2015-02-01
影响因子：
4.4
通讯作者：
Fleckenstein, Monika
中科院分区：
文献类型：
--
作者：
Lindner, Moritz;Bezatis, Athanasios;Fleckenstein, Monika
目的。分析年龄相关性黄斑变性（AMD）继发地理性萎缩（GA）眼的脉络膜厚度（CT）。共聚焦扫描激光检眼镜和增强深度成像（EDI）光谱域光学相干断层扫描检查了72例GA患者（平均年龄75.97 +/- 7.09岁）的72只眼和37例健康对照（73.89 +/- 6.19岁）的37只眼。在水平和垂直扫描中测量25个定义点的脉络膜厚度。在眼底自身荧光（FAF）图像中测定地理萎缩大小，并根据病灶周围区域FAF异常分类GA亚型。在GA中，中央凹下CT （fCT）较对照组明显变薄（173.03 +/- 90.22 vs. 253.95 +/- 69.19 μ m, P < 0.001）。分析每位患者获得的所有25个点的平均测量结果（mCT）显示相似的结果（162.07 +/- 76.26 vs 228.00 +/- 66.24 μ m, P < 0.001）。两组CT空间差异最大，优于中央凹。分别对“扩散-滴流”组（n = 15）和“非扩散-滴流”组（n = 57） GA进行分析，fCT值分别为114.67 +/- 43.32和188.39 +/- 93.26 μ m (P = 0.002)，两组均显著小于对照组（“扩散-滴流”组P < 0.001，“非扩散-滴流”组P < 0.001）。mCT试验结果相似，扩散滴注组为110.21 +/- 29.66 μ m，非扩散滴注组为175.72 +/- 79.02 μ m，对照组为228.00 6 66.24 μ m。GA组与P = 0.002，差异有统计学意义
PURPOSE. To analyze choroidal thickness (CT) in eyes with geographic atrophy (GA) secondary to age-related macular degeneration (AMD).METHODS. A total of 72 eyes of 72 patients (mean age, 75.97 +/- 7.09 years) with GA and 37 eyes of 37 healthy controls (73.89 +/- 6.19 years) were examined by confocal scanning laser ophthalmoscopy and enhanced depth imaging (EDI) spectral-domain optical coherence tomography. Choroidal thickness was measured at 25 defined points in horizontal and vertical scans. Geographic atrophy size was determined in fundus autofluorescence (FAF) images and GA subtypes were classified based on abnormal FAF in the perilesional zone.RESULTS. In GA, subfoveal CT (fCT) was significantly thinner compared to controls (173.03 +/- 90.22 vs. 253.95 +/- 69.19 mu m, P < 0.001). Analysis of averaged measurements of all 25 points obtained per patient (mCT) revealed similar results (162.07 +/- 76.26 vs. 228.00 +/- 66.24 mu m, P < 0.001). Spatial differences in CT between both groups were largest superior to the fovea. Addressing "diffuse-trickling'' (n = 15) and "non-diffuse-trickling'' (n = 57) GA independently, fCT was 114.67 +/- 43.32 and 188.39 +/- 93.26 mu m, respectively (P = 0.002), with both groups being significantly thinner than controls (P < 0.001 for "diffuse-trickling'' and P < 0.001 for "non-diffuse-trickling''). Similar results were obtained for mCT, which was 110.21 +/- 29.66 mu m in "diffuse-trickling,'' 175.72 +/- 79.02 mu m in "non-diffuse-trickling'' and 228.00 6 66.24 lm in controls. Differences were significant with P = 0.002 between both GA groups and P