Transplantation in HIV-infected subjects: is cure possible?
Transplantation in HIV-infected subjects: is cure possible?
复制标题
HIV感染者的移植：可能治愈吗？
DOI：
10.1182/asheducation-2013.1.389
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
S. Forman
中科院分区：
文献类型：
--
作者：
J. Zaia;S. Forman
随着有效的抗逆转录病毒疗法的出现，艾滋病毒相关恶性肿瘤，特别是淋巴瘤患者的治疗有了很大的改善，产生的结果与艾滋病毒无关的淋巴瘤患者相当。造血干细胞移植平台促进了基因修饰干细胞的研究，这些干细胞被设计为表达抗逆转录病毒基因以抵抗艾滋病毒感染，测试了这些细胞的植入将导致艾滋病毒耐药性和消除病毒库的概念体内。在HIV和淋巴瘤患者中的结果现在已经导致了将在没有伴随恶性肿瘤的HIV患者中测试这些原则的研究。此外，在患有HIV和急性髓性白血病的患者中，从携带CCR5基因突变的无关供体进行同种异体移植的成功证明，原则上，这种方法也可以治愈HIV患者。对接受同种异体移植的艾滋病毒白血病患者的病例研究也表明，对艾滋病毒储库可能有治疗作用，这可能会改变艾滋病毒在同种异体环境中的自然史。
With the advent of effective antiretroviral therapy, the treatment of patients with HIV-related malignancies, especially lymphoma, has greatly improved, yielding results comparable to those seen in patients with lymphoma unrelated to HIV. The platform of transplantation of hematopoietic stem cells has facilitated studies of genetically modified stem cells engineered to express antiretroviral genes to resist infection by the HIV virus, testing the concept that engraftment of these cells will lead to HIV resistance and elimination of the reservoir of virus in the body. Results in patients with HIV and lymphoma have now led to studies that will test these principles in HIV patients without concomitant malignancy. In addition, in a patient with HIV and acute myeloid leukemia, the success of an allogeneic transplantation from an unrelated donor carrying a mutation in the CCR5 genes has demonstrated that, in principle, such an approach could also lead to cure of patients with HIV. Case studies in HIV patients with leukemia undergoing allogeneic transplantation also suggest that there may be a therapeutic effect on the HIV reservoir that could alter the natural history of HIV in the allogeneic setting.
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影响因子：
20.3
作者：
Biggar, Robert J.;Jaffe, Elaine S.;Engels, Eric A.
通讯作者：
Engels, Eric A.
减少剂量白消安、环磷酰胺和自体干细胞移植治疗人类免疫缺陷病毒相关淋巴瘤：艾滋病恶性肿瘤联盟研究 020。
DOI：
10.1016/j.bbmt.2007.03.014
发表时间：
2008
期刊：
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
影响因子：
--
作者：
Spitzer,ThomasR;Ambinder,RichardF;Lee,JeannetteY;Kaplan,LawrenceD;Wachsman,William;Straus,DavidJ;Aboulafia,DavidM;Scadden,DavidT
通讯作者：
Scadden,DavidT
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
39.2
作者：
HOLLAND, HK;SARAL, R;SANTOS, GW
通讯作者：
SANTOS, GW