Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.
Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis.
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DOI：
10.1183/13993003.01012-2016
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Goletti D
中科院分区：
文献类型：
--
作者：
Petruccioli E;Scriba TJ;Petrone L;Hatherill M;Cirillo DM;Joosten SA;Ottenhoff TH;Denkinger CM;Goletti D
需要新的方法来控制结核病（TB）的传播，包括预测从潜伏结核感染（LTBI）发展为活动性结核病的工具。最近的研究描述了风险的潜在相关性，以便为结核病进展的预后测试的开发提供信息。这些努力包括采用“组学”技术的公正方法，以及更直接、假设驱动的方法，评估一小部分甚至单个选定的标记作为结核病风险的候选相关性。对血液 RNAseq 谱进行无偏倚的高通量筛查，可在诊断前 1 年以上确定 LTBI 患者的活动性结核病风险特征。最近的一项婴儿疫苗接种研究发现，T 细胞激活标记物的表达增强与罹患结核病的风险相关；相反，高水平的 Ag85A 抗体和高频率的干扰素 (IFN)-γ 特异性 T 细胞与疾病风险降低相关。其他人将 CD27−IFN-γ+CD4+ T 细胞描述为结核病的可能预测标志物。 T 细胞对结核潜伏抗原（包括肝素结合血凝素和 DosR 调节子编码抗原）的反应也与保护相关。需要进一步的研究来确定是否可以利用风险相关性通过有针对性的预防性治疗来预防活动性结核病，或者允许有针对性地参加新结核病疫苗和治疗药物的功效试验。有前途的生物标志物可以准确预测从感染到活动性结核病的进展http://ow.ly/OzCL304ezfk
New approaches to control the spread of tuberculosis (TB) are needed, including tools to predict development of active TB from latent TB infection (LTBI). Recent studies have described potential correlates of risk, in order to inform the development of prognostic tests for TB disease progression. These efforts have included unbiased approaches employing “omics” technologies, as well as more directed, hypothesis-driven approaches assessing a small set or even individual selected markers as candidate correlates of TB risk. Unbiased high-throughput screening of blood RNAseq profiles identified signatures of active TB risk in individuals with LTBI, ≥1 year before diagnosis. A recent infant vaccination study identified enhanced expression of T-cell activation markers as a correlate of risk prior to developing TB; conversely, high levels of Ag85A antibodies and high frequencies of interferon (IFN)-γ specific T-cells were associated with reduced risk of disease. Others have described CD27−IFN-γ+CD4+ T-cells as possibly predictive markers of TB disease. T-cell responses to TB latency antigens, including heparin-binding haemagglutinin and DosR-regulon-encoded antigens have also been correlated with protection. Further studies are needed to determine whether correlates of risk can be used to prevent active TB through targeted prophylactic treatment, or to allow targeted enrolment into efficacy trials of new TB vaccines and therapeutic drugs. Promising biomarkers may allow accurate prediction of progression from infection to active TB disease http://ow.ly/OzCL304ezfk
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影响因子：
3.7
作者：
Aggerbeck, Henrik;Giemza, Rafaela;Lewis, David J. M.
通讯作者：
Lewis, David J. M.
DOI：
10.4049/jimmunol.1101122
发表时间：
2011-09-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Day CL;Abrahams DA;Lerumo L;Janse van Rensburg E;Stone L;O'rie T;Pienaar B;de Kock M;Kaplan G;Mahomed H;Dheda K;Hanekom WA
通讯作者：
Hanekom WA
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
2.5
作者：
Cantini, Fabrizio;Lubrano, Ennio;Spadaro, Antonio
通讯作者：
Spadaro, Antonio
影响因子：
3.9
作者：
Cantini, Fabrizio;Niccoli, Laura;Goletti, Delia
通讯作者：
Goletti, Delia