VASCULAR REACTIONS TO HISTAMINE, HISTAMINE-LIBERATOR AND LEUKOTAXINE IN THE SKIN OF GUINEA-PIGS
VASCULAR REACTIONS TO HISTAMINE, HISTAMINE-LIBERATOR AND LEUKOTAXINE IN THE SKIN OF GUINEA-PIGS
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DOI：
10.1113/jphysiol.1952.sp004789
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发表时间：
1952-01-01
影响因子：
5.5
通讯作者：
MILES, EM
中科院分区：
文献类型：
--
作者：
MILES, AA;MILES, EM
用豚鼠躯干和耳皮肤皮内注射致蓝色损伤的大小和强度来测定毛细血管通透性的增加。组胺，组胺释放剂48/80，和白细胞介素，在动物与Pontamine天蓝6 X在他们的循环。在躯干中，这些药物在恒定体积中的分级剂量的平均病变直径与对数成比例。剂量，并在分级注射恒定剂量。它与对数成正比。音量.对组胺、48/80和白细胞介素的线性剂量反应形成了“恒定体积”滴定中测定方法的基础;“恒定剂量”测量可用于测量皮肤组织对这3种物质的亲和力。结果进行了详细讨论。
The increase in capillary permeability in the skin of the trunk and ear of guinea pigs was measured by the size and intensity of the blue lesion induced by the intradermal injn. of histamine, the histamine-liberator 48/80, and leukotaxine, in animals with pontamine sky blue 6 X in their circulation. In the trunk the mean lesion-diameter from graded doses of these drugs in a constant volume is proportional to the log. dose, and for a constant dose in graded injn.-volumes it is proportional to the log. volume. The linear dosage-response to histamine, 48/80 and leukotaxine forms the basis of an assay method in the "constant-volume" titration; "constant dose" measurements can be used to measure the affinity of skin tissue for the 3 substances. The results are discussed in great detail.