Biocompatibility, corrosion resistance and antibacterial activity of TiO2/CuO coating on titanium
Biocompatibility, corrosion resistance and antibacterial activity of TiO2/CuO coating on titanium
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钛表面TiO2/CuO涂层的生物相容性、耐腐蚀性及抗菌活性
DOI：
10.1016/j.ceramint.2017.08.196
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发表时间：
2017-12-15
影响因子：
5.2
通讯作者：
Zhang, Xiangyu
中科院分区：
文献类型：
--
作者：
He, Xiaojing;Zhang, Guannan;Zhang, Xiangyu
本文采用磁控溅射和热处理相结合的方法在钛表面制备了TiO2CuO涂层。研究了TiO2CuO涂层的组织结构、生物相容性、耐腐蚀性和抗菌性能，并与纯钛和TiO2涂层进行了比较。结果表明，TiO2CuO涂层主要由TiO2CuO组成。体外细胞相容性评价表明，TiO2CuO涂层无明显毒性，涂层可促进成骨细胞的铺展和增殖。与钛涂层和二氧化钛涂层相比，二氧化钛/氧化铜涂层具有更好的耐腐蚀性和抗菌能力。本研究首次尝试将磁控溅射与热处理相结合，将铜引入二氧化钛涂层中，对钛基种植体材料进行表面改性，为进一步开发生物活性多功能涂层提供研究基础，以满足更好的临床需求。
In this work, TiO2/CuO coating was prepared on titanium (Ti) by combination of magnetron sputtering and annealing treatment. The microstructure, biocompatibility, corrosion resistance and antibacterial property of TiO2/CuO coating were investigated in comparison with pure Ti and TiO2 coating. The results show that TiO2/CuO coating is mainly composed of TiO2 and CuO. In vitro cytocompatibility evaluation suggests that no obvious toxicity appears on the TiO2/CuO coating, and the coating stimulates the osteoblast spreading and proliferation. Compared with Ti and TiO2 coating, TiO2/CuO coating exhibits improved corrosion resistance and antibacterial ability against S.aureus. This study is the first attempt to apply the combination of magnetron sputtering and annealing treatment to introduce the Cu into TiO2 coating for surface modification of Ti-based implant materials, which may provide a research foundation for further development of bioactive multifunctional coatings to meet the better clinical demand.