Diabetic bladder dysfunction: current translational knowledge.
Diabetic bladder dysfunction: current translational knowledge.
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DOI：
10.1016/j.juro.2009.08.070
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发表时间：
2009-12
期刊：
影响因子：
--
通讯作者：
Chacko S
中科院分区：
文献类型：
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作者：
Daneshgari F;Liu G;Birder L;Hanna-Mitchell AT;Chacko S
糖尿病（DM）是一种由胰岛素绝对或相对缺乏引起的代谢紊乱，是一种具有多种严重并发症的衰弱和昂贵的疾病。下尿路（LUT）并发症是糖尿病最常见的并发症之一。糖尿病最常见和最麻烦的LUT并发症是糖尿病膀胱病或糖尿病膀胱功能障碍（DBD）。我们回顾了目前的DBD翻译知识。我们通过PUBMED对英文文献进行了检索。使用的关键词是“糖尿病”和“膀胱功能障碍”或“膀胱病”。我们的数据和观点提供了考虑未来的研究方向。尽管传统上认为DBD是一种排尿问题，其特征在于排空不良和溢流性尿失禁，但最近的临床和实验证据表明DM中存在储存问题，如尿急和急迫性尿失禁。最近的实验证据，从研究的DBD的小动物模型的DM，表明存在的时间效应的DBD：早期阶段的DM的原因补偿膀胱功能;和晚期阶段的DM的原因失代偿膀胱功能。“时间理论”可以合理地为临床和实验结果之间的相关性提供科学的路线图，以及确定多尿、高血糖、氧化应激、自主神经病变和膀胱收缩器官失代偿等机制在DBD临床和实验表现中的作用。DBD包括储存和排空问题的时间依赖性表现。识别机制途径将引导我们识别治疗干预。
Diabetes mellitus (DM) is a metabolic disorder caused by an absolute or relative deficiency of insulin, a debilitating and costly disease with multiple serious complications. Lower urinary tract (LUT) complications are among the most common complications of DM. The most common and bothersome LUT complication of DM is diabetic cystopathy, or diabetic bladder dysfunction (DBD). We reviewed the current translational knowledge of DBD. We performed a search of the English literature through PUBMED. The key words used were “diabetes” and “bladder dysfunction” or “cystopathy”. Our data and perspective are provided for consideration of future direction of research. Despite traditional recognition of DBD, as a voiding problem, characterized by poor emptying and overflow incontinence, recent clinical and experimental evidence indicate a presence of storage problems such as urgency, and urge incontinence in DM. Recent experimental evidence from studies of DBD on small animal models of DM, indicate the presence of a temporal effect on DBD: Early phase of DM causes compensated bladder function; and late phase of DM causes decompensated bladder function. The ‘temporal theory’ could plausibly provide the scientific road map for correlation between clinical and experimental findings as well as identification of role of mechanisms such as polyuria, hyperglycemia, oxidative stress, autonomic neuropathy and decompensation of contractile apparatus of the bladder in creation of clinical and experimental manifestations of the DBD. DBD includes time-dependent manifestations of storage and emptying problems. Identification of mechanistic pathways would lead us to identification of therapeutic intervention.