Accumulation of beta-carotene in normal colorectal mucosa and colonic neoplastic lesions in humans.
Accumulation of beta-carotene in normal colorectal mucosa and colonic neoplastic lesions in humans.
复制标题
β-胡萝卜素在人类正常结直肠粘膜和结肠肿瘤病变中的积累。
DOI：
10.1080/01635589509514390
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Mobarhan,S
中科院分区：
文献类型：
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作者：
Maiani,G;Pappalardo,G;Ferro-Luzzi,A;Raguzzini,A;Azzini,E;Guadalaxara,A;Trifero,M;Frommel,T;Mobarhan,S
相对于在正常结肠和直肠组织中积累的量，确定在人体原位结肠息肉和结肠癌组织中积累的β-胡萝卜素（BC）的量。通过高效液相色谱法测定口服补充BC（30 mg/天）前后获得的样本中BC、视黄醇和α-生育酚的血清浓度以及组织BC浓度。在对照组、息肉组和癌症患者中，血清BC和视黄醇浓度响应于补充而显著增加，但血清α-生育酚浓度没有变化。癌症患者的组织（结肠、直肠和肿瘤）中的BC浓度显著低于来自对照和息肉患者的组织样品中的BC浓度。相对于基线值，在补充期间，BC在来自所有患者的组织（包括息肉和肿瘤组织）中累积到显著程度。结果表明，BC确实在人类结肠肿瘤组织中积累，并且可能潜在地用于增强化疗药物的细胞毒性或防止细胞的恶性转化。
The quantity of β‐carotene (BC) accumulated in colonic polyps and colonic cancererous tissue in humansin situwas determined relative to the quantity accumulated in normal colon and rectal tissue. Serum concentration of BC, retinol, and α‐tocopherol and tissue BC concentration were determined by high‐performance liquid chromatography in samples obtained before and after oral supplementation with BC (30 mg/day). The serum BC and retinol concentrations significantly increased in response to supplementation in control, polyp, and cancer patients, but there was no change in serum α‐tocopherol concentration. The BC concentration in tissue (colon, rectum, and tumor) of cancer patients was significantly less than that in tissue samples from control and polyp patients. Relative to baseline values, BC accumulated to a significant extent in tissues from all patients, including polyp and tumor tissue, during supplementation. The results indicate that BC does accumulate in colonic neoplastic tissue in humans and may potentially be utilized to augment cytotoxicity of chemotherapeutics or to prevent malignant transformation of cells.