Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules.
Therapeutic New Era for Atopic Dermatitis: Part 2. Small Molecules.
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DOI：
10.5021/ad.2021.33.2.101
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发表时间：
2021-04
影响因子：
1.6
通讯作者：
Simpson EL
中科院分区：
文献类型：
--
作者：
Ahn J;Choi Y;Simpson EL
特应性皮炎（AD）是一种由免疫失调和皮肤屏障功能障碍引起的慢性炎症性皮肤疾病。目前，我们正在经历一个了解AD发病机制的新时代，因此，一个治疗创新的新时代，包括小分子和生物治疗。与生物制剂相比，小分子类似于用作药物的常规药理学化学试剂，并且通常通过化学合成制备。与生物制剂不同，这些药物通常口服或配制用于局部使用。本综述的目的是通过回顾最近发表的关于目前正在进行2期或3期临床试验的治疗方法的论文，总结目前AD局部和全身新疗法的疗效和安全性。在本综述中，重要的是要注意研究人群的特征、主要终点以及是否允许伴随局部治疗。这些研究设计要素可能会显著改变研究结果，应予以考虑。靶向治疗有助于将AD治疗推向个性化医疗的新时代。
Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. In contrast to biologics, small molecules are similar to conventional pharmacologic chemical agents used as drugs and are generally prepared by chemical synthesis. Unlike biologics, these drugs often are taken orally or formulated for topical use. The purpose of this review is to summarize the efficacy and safety of the current topical and systemic new therapies in AD by reviewing recently published papers on therapies currently in phase 2 or 3 clinical trials. In this review, it is important to note the characteristics of the study population, the primary endpoints, and whether or not there was concomitant topical therapy allowed. These study design elements may significantly alter the results of studies and should be taken into account. Targeted therapy help push AD treatment into a new era of personalized medicine.
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