Level ofOpisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters
Level ofOpisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in Syrian golden hamsters
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叙利亚金仓鼠后睾吸虫感染水平和致癌物诱导胆管癌的剂量依赖性
DOI：
10.1007/bf02899196
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
M. Moore
中科院分区：
文献类型：
--
作者：
W. Thamavit;Rungtiva Kongkanuntn;D. Tiwawech;M. Moore
摘要本文研究了叙利亚金仓鼠不同水平肝吸虫、毒腹蛇（Opisthorchis viverrini）侵染与二甲亚硝胺（DMN）剂量诱导胆管癌的关系。280只断奶公鼠分为4组：第一组为未处理对照组；第二组接收到do。每只动物只有100、50、25或12个囊蚴；3组仅接受剂量为12.5、6.25或3.125 ppm的DMN；第4组采用囊蚴与DMN的不同组合。在接受12.5 ppm DMN的第3组中，17只动物中只有2只（12%）有可检测到的肿瘤，在6.25和3.125 ppm DMN亚组中，或在单独的寄生虫或未治疗的对照仓鼠中未见肿瘤病变。相比之下，在第4组中观察到高致癌物和寄生虫剂量依赖性胆管癌（发生率高达93%）和推定的肿瘤前胆管纤维化病变。因此，研究结果表明，这两种药物具有明显的剂量依赖性协同效应，并揭示了寄生虫的存在对DMN诱导胆管癌变的至关重要，即使寄生虫的水平低至12个囊蚴。
SummaryThe relationship between different levels of liver fluke,Opisthorchis viverrini infestation and dimethylnitrosamine (DMN) dosage in the induction of cholangiocarcinomas was investigated in Syrian golden hamsters. Two hundred and eighty male, weanling animals were divided into 4 groups: Group 1 served as untreated controls; group 2 receivedO. viverrini metacercariae only at levels of 100, 50, 25 or 12 per animal; group 3 received DMN only at doses of 12.5, 6.25 or 3.125 ppm; group 4 received various combinations of metacercariae and DMN. Only 2 of 17 animals (12%) in group 3 receiving 12.5 ppm had detectable tumours and no neoplastic lesions were seen in the 6.25 and 3.125 ppm DMN subgroups or in parasite alone or untreated control hamsters. In contrast, high carcinogen and parasite dose-dependent yields of cholangiocarcinomas (incidences up to 93%) and putative preneoplastic cholangiofibrotic lesions were observed in group 4. Thus the results indicate clear dose-dependent synergistic effects for the two agents and reveal the crucial importance of the presence of parasite, even at levels as low as 12 metacercariae, for DMN induction of bile duct carcinogenesis.
急性肝坏死在二乙基亚硝胺诱导肝癌早期步骤中的作用。
影响因子：
11.2
作者：
Ying,TS;Sarma,DS;Farber,E
通讯作者：
Farber,E
叙利亚金仓鼠大剂量黄曲霉毒素 B1 诱发胆管细胞癌。
DOI：
--
发表时间：
1982
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Moore,MR;Pitot,HC;Miller,EC;Miller,JA
通讯作者：
Miller,JA
通过三种不同的程序测定细胞增殖对肝癌发生的启动的要求。
影响因子：
11.2
作者：
Columbano,A;Rajalakshmi,S;Sarma,DS
通讯作者：
Sarma,DS