Bioactive constituents of Morus australis and Broussonetia papyrifera
Bioactive constituents of Morus australis and Broussonetia papyrifera
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DOI：
10.1021/np970186o
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发表时间：
1997-10-01
影响因子：
5.1
通讯作者：
Lin, CN
中科院分区：
文献类型：
--
作者：
Ko, HH;Yu, SM;Lin, CN
对桑科两种植物的有效成分进行了生物活性研究。从桑根皮中分离得到一个新的异戊烯基黄酮类化合物australone A（1）和一个新的三萜类化合物3 beta-[（m-methoxybenzoyl）oxy]urs-12-en-28-oic acid（2）。从该植物中还分离出7个已知化合物，morusin（3）、kuwanon C（4）、桦木酸、β-香树脂醇、槲皮素、熊果酸和化合物A。Morusin（3）对花生四烯酸、胶原和PAF诱导的血小板聚集有显著影响，而Kuwanon C（4）对花生四烯酸和PAF诱导的血小板聚集有活性。在对第二种植物的生物学研究中，构叶树、构叶树黄酮醇F（5）和G（6）、构叶树黄酮A（7）和构叶树橙酮A（8）有效地抑制了大鼠脑匀浆中Fe 2+诱导的脂质氧化。化合物5-7还显著抑制大鼠血管平滑肌细胞的增殖。
The biological activities of the active principles of two plants in the Moraceae have been investigated. A new prenylflavonoid, australone A (1), and a new triterpenoid, 3 beta-[(m-methoxybenzoyl)oxy]urs-12-en-28-oic acid (2) were isolated from the root bark of Morus australis, and their structures determined by spectroscopic methods. Also isolated from this plant were seven known compounds, morusin (3), kuwanon C (4), betulinic acid, beta-amyrin, quercetin, ursolic acid, and compound A. Morusin (3) showed significant effects on arachidonic acid-, collagen-, and PAF-induced platelet aggregation, while kuwanon C (4) was active in the arachidonic acid- and PAF-induced platelet aggregation assays. In biological work on a second plant, Broussonetia papyrifera, broussoflavonols F (5) and G (6), broussoflavan A (7), and broussoaurone A (8) potently inhibited Fe2+-induced lipid oxidation in rat-brain homogenate. Compounds 5-7 also significantly inhibited the proliferation of rat vascular smooth muscle cells.