IMPULSE CONDUCTION PROPERTIES OF NORADRENERGIC LOCUS COERULEUS AXONS PROJECTING TO MONKEY CEREBROCORTEX
IMPULSE CONDUCTION PROPERTIES OF NORADRENERGIC LOCUS COERULEUS AXONS PROJECTING TO MONKEY CEREBROCORTEX
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DOI：
10.1016/0306-4522(85)90077-6
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发表时间：
1985-01-01
期刊：
影响因子：
3.3
通讯作者：
SEGAL, M
中科院分区：
文献类型：
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作者：
ASTONJONES, G;FOOTE, SL;SEGAL, M
在麻醉松鼠猴的大脑皮质和丘脑区接受电刺激时，记录到含去甲肾上腺素的蓝斑神经元的逆行驱动动作电位。这些细胞可靠地从距离蓝斑100 mm的皮质部位传导脉冲。猴蓝斑神经元表现出多种特性，包括缓慢的自发放电频率、特征性的脉冲波形、许多靶区的逆行激活、逆行或顺行驱动后的一段时间的抑制活动以及对伤害性刺激的反应。对后脚的电刺激。大量的猴子蓝斑神经元表现出比以前在大鼠身上发现的更快的传导速度(例如，apprx。34%为1m/S)，导致2个SPP中远距离靶区的传导潜伏期相似。蓝斑冲动到达远距离靶区所需的传导时间在不同物种和不同大小的脑中可能是保守的，这表明这些潜伏期在蓝斑系统在脑和行为过程中的一般功能中发挥着重要作用。
Antidromically driven action potentials were recorded from norepinephrine-containing locus coeruleus neurons in response to electrical stimulation of cerebrocortical and thalamic areas in anesthetized squirrel monkeys. These cells reliably conducted impulses from cortical sites of distances up to 100 mm from locus coeruleus. Monkey locus coeruleus neurons exhibited several properties previously described for these cells in rat, including slow spontaneous discharge rates, characteristic impulse waveforms, antidromic activation from many target areas, a period of suppressed activity following either antidromic or orthodromic driving and responsiveness to noxious stimuli presented as s.c. electrical stimulation of a rear foot. A large population of monkey locus coeruleus neurons exhibited more rapid conduction velocities than previously found for rat (e.g., .apprx. 34% were > 1 m/s), resulting in similar conduction latencies to distant target areas in the 2 spp. The conduction times required for locus coeruleus impulses to reach distant target areas may be conserved across different species and sizes of brains, suggesting that these latencies play an important role in the general function of the locus coeruleus system in brain and behavioral processes.