Lung inflation inhibits rapidly adapting receptor relay neurons in the rat
Lung inflation inhibits rapidly adapting receptor relay neurons in the rat
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DOI：
10.1097/00001756-200006050-00023
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发表时间：
2000-06-05
期刊：
影响因子：
1.7
通讯作者：
Tanaka, I
中科院分区：
文献类型：
--
作者：
Ezure, K;Tanaka, I
肺慢适应受体（SAR）和肺快适应受体（RAR）是各种呼吸反射的重要组成部分。在麻醉，麻痹和人工通气大鼠，我们发现了一个抑制链接，从前者到后者的系统在其二级中继神经元（P细胞和RAR细胞，分别）的水平。激活RAR和SAR的肺膨胀抑制迷走神经电刺激诱发的RAR细胞活性。RAR细胞的细胞内记录显示IPSPs锁定在同侧和对侧迷走神经的电刺激强度略高于P细胞激活的阈值。用谷氨酸激活P细胞抑制RAR细胞放电。由于P细胞投射到RAR细胞的区域，因此这些结果一起强烈地表明P细胞突触抑制RAR细胞。NeuroReport 11：1709-1712（C）2000 Lippincott威廉姆斯和威尔金斯。
Pulmonary slowly adapting receptors (SARs) and rapidly adapting receptors (RARs) are important components of various respiratory reflexes. In anesthetized, paralyzed and artificially ventilated rats, we found an inhibitory linkage from the former to the latter system at the level of their second-order relay neurons (P cells and RAR cells, respectively). Lung inflation which activates RARs as well as SARs suppressed RAR cell activity evoked by electrical stimulation of the vagus nerve. Intracellular recordings from RAR cells showed IPSPs locked to electrical stimulation of the ipsilateral and contralateral vagus nerves at an intensity just above the threshold for P cell activation. Activation of P cells with glutamate suppressed RAR cell firing. Since P cells project to the area of RAR cells, taken together, these results strongly suggest that P cells synaptically inhibit RAR cells. NeuroReport 11:1709-1712 (C) 2000 Lippincott Williams & Wilkins.