Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice.
Effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga mice.
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他克莫司水合物 (FK506) 软膏对 NC/Nga 小鼠自发性皮炎的影响。
DOI：
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
K. Esaki
中科院分区：
文献类型：
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作者：
J. Hiroi;T. Sengoku;K. Morita;S. Kishi;S. Sato;T. Ogawa;M. Tsudzuki;H. Matsuda;A. Wada;K. Esaki
考察了他克莫司水合物（FK 506）软膏对NC/Nga（NC）小鼠自发性皮炎的影响。FK 506软膏（0.1-1%）抑制皮炎的发展，对已建立的皮炎也有治疗效果。在NC小鼠的皮肤中证实了CD 4阳性T细胞（辅助性T细胞）、肥大细胞、嗜酸性粒细胞和白细胞介素（IL）-4，IL-5和IgE的免疫染色增加，FK 506软膏抑制了所有这些变化。在NC小鼠中也证实了血浆IgE升高，FK 506软膏给药降低了血浆IgE水平。这些结果表明，FK 506通过抑制炎症细胞的活化和阻断NC小鼠皮肤中的细胞因子网络来抑制皮炎。市售的类固醇软膏对皮炎的发展仅显示出轻微的作用，并显示出一些副作用的迹象，如脱发或皮肤萎缩。这些副作用可能掩盖了类固醇的作用，因为类固醇对皮肤组织病理学变化和血浆IgE升高显示出相似的抑制作用。从这些结果来看，FK 506软膏有望成为治疗特应性皮炎的有效药物。
The effect of tacrolimus hydrate (FK506) ointment on spontaneous dermatitis in NC/Nga (NC) mice was examined. FK506 ointment (0.1-1%) suppressed the development of dermatitis and was also therapeutically effective against established dermatitis. Increases in CD4-positive T cells (helper T cells), mast cells, eosinophils and immunostaining of interleukin (IL)-4, IL-5 and IgE were confirmed in the skin of the NC mice, and FK506 ointment suppressed all of these changes. Increased plasma IgE was also confirmed in the NC mice, and treatment with FK506 ointment reduced the plasma IgE level. These results suggested that FK506 suppressed the dermatitis by inhibiting the activation of inflammatory cells and by blocking the cytokine network in the skin of the NC mice. The commercially available steroid ointments showed only marginal effect on the development of dermatitis and showed some signs of side effects such as alopecia or atrophy of the skin. The effect of the steroids might have been masked by these side effects because the steroids showed similar inhibitory effects on the skin histopathological changes and the increase of plasma IgE. From these results, FK506 ointment can be expected to be a useful drug for atopic dermatitis.
使用淋巴器官的细胞提取物通过被动皮肤过敏反应检测 IgE 抗体形成细胞。
影响因子：
2.2
作者：
Watanabe,N;Kobayashi,A;Miyajima,H;Hirano,T;Ovary,Z
通讯作者：
Ovary,Z