A review of the use of latanoprost for glaucoma since its launch.
A review of the use of latanoprost for glaucoma since its launch.
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DOI：
10.1517/14656566.2012.662219
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发表时间：
2012-04-01
影响因子：
3.2
通讯作者：
Rossetti, Luca
中科院分区：
文献类型：
--
作者：
Digiuni, Maurizio;Fogagnolo, Paolo;Rossetti, Luca
简介：前列腺素越来越多地被用作青光眼的首选治疗方法，因为它们非常有效，没有相关的全身副作用，并且只需每天给药一次。拉坦前列素是前列腺素F2 α的酯前药类似物，通过增加葡萄膜巩膜流出量降低眼内压（IOP）。拉坦前列素0.005%已获得欧洲和美国批准，作为降低开角型青光眼或高眼压患者IOP的一线药物。随着Xalatan最近的专利到期，一些拉坦前列素仿制药已进入青光眼市场。涵盖领域：本综述通过PubMed和Medline研究方法实现，描述了拉坦前列素的组成，药代动力学，作用模式，疗效，副作用和安全性。专家意见：拉坦前列素是第一个引入青光眼治疗的前列腺素类似物，由于其疗效和安全性，它极大地改变了该疾病的市场。使用拉坦前列素后常见的结膜充血与小梁切除术的疗效和持续时间较小相关;然而，从眼科医生的角度来看，这种副作用似乎在很大程度上被这种化合物的高疗效和安全性所抵消。始终建议考虑拉坦前列素的促炎作用模式，因为这可能对特定患者产生负面影响（即，患有葡萄膜炎和囊样黄斑水肿的患者），对于这些患者，需要谨慎和密切随访。
INTRODUCTION: Prostaglandins are increasingly used as first choice treatment for glaucoma because they are highly effective, lack relevant systemic side effects and require just once-daily administration. Latanoprost is an ester prodrug analog of prostaglandin F2alpha, which reduces intraocular pressure (IOP) by increasing uveoscleral outflow. Latanoprost 0.005% has received European and US approval as the first-line drug for reducing IOP in patients with open-angle glaucoma or ocular hypertension. Following the recent patent expiry for Xalatan, a number of latanoprost generics have entered the glaucoma market.AREAS COVERED: This review, achieved through PubMed and Medline research methods, describes the composition, pharmacokinetics, mode of action, efficacy, side effects and safety profile of latanoprost.EXPERT OPINION: Latanoprost was the first prostaglandin analog introduced in glaucoma management and it dramatically changed the market of the disease thanks to its efficacy and safety. Conjunctival hyperemia, which is commonly found after latanoprost use, is associated with a minor efficacy and duration of trabeculectomy; yet, from the ophthalmologist's perspective, this side effect seems largely counterbalanced by the high efficacy and safety of this compound. It is always advisable to consider the pro-inflammatory mode of action of latanoprost because this may have negative effects in particular patients (i.e., those with uveitis and cystoid macular edema) for whom caution and close follow-up is necessary.