Retinal pigment epithelial correlates of avian retinal degeneration: Electron microscopic analysis
Retinal pigment epithelial correlates of avian retinal degeneration: Electron microscopic analysis
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视网膜色素上皮与禽类视网膜变性的相关性：电子显微镜分析
DOI：
10.1002/cne.902310303
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发表时间：
1985
影响因子：
2.5
通讯作者：
P. Doran
中科院分区：
文献类型：
--
作者：
K. Fite;L. Bengston;P. Doran
家鸡的迟发性无黑色素（DAM）品系的特征在于脉络膜炎症的早期发育发作以及羽毛和脉络膜黑色素细胞的破坏。其次，视乳头周围区域的视网膜色素上皮（RPE）细胞出现异常，并出现一系列进行性组织病理学变化，包括RPE黑色素颗粒减少和最终丧失以及RPE细胞萎缩。RPE细胞异常的最早迹象是细胞内黑色素颗粒分布的显著改变。顶突还显示与感光器外节的接触减少，导致在更高级的阶段中其回缩和视网膜脱离的发展。RPE细胞中的其他进行性改变包括基底内折叠的解体和损失;从早期到晚期阶段线粒体和髓样体的尺寸减小和密度增加;视网膜下腔中出现大巨噬细胞;细胞间连接复合物的损失;以及黑色素颗粒密度的进行性降低。这些异常似乎以一个细胞接一个细胞的放射状模式扩散，直到视网膜的广泛区域变得严重病理性和萎缩。DAM脉络膜视网膜疾病似乎表现出许多组织病理学特征，这些特征是实验诱导的葡萄膜炎和其他眼部疾病，这些疾病可能是由对葡萄膜色素的超敏反应或自身免疫反应引起的。
The delayed amelanotic (DAM) strain of domestic chicken is characterized by an early, developmental onset of choroidal inflammation and destruction of both feather and choroidal melanocytes. Secondarily, retinal pigment epithelial (RPE) cells in the peripapillary region develop abnormalities, and a series of progressive histopathological changes ensues which includes reduction and ultimate loss of RPE‐melanin granules and RPE‐cell atrophy. The earliest sign of RPE‐cell abnormality is a dramatic alteration in the distribution of intracellular melanin granules. Apical processes also show a lessening of contact with photoreceptor outer segments, leading in more advanced stages to their retraction and development of retinal detachments. Other progressive alterations in RPE cells include disorganization and loss of basal infoldings; size reductions and density increases in both mitochondria and myeloid bodies from early to advanced stages; appearance of large macrophages in the subretinal space; loss of intercellular junctional complexes; and progressive reduction in the density of melanin granules. These abnormalities appear to spread in a cell‐by‐cell, radial pattern, until widespread areas of the retina become severely pathologic and atrophic. The DAM chorioretinal disorder appears to show many of the histopathologic features which characterize experimentally induced uveitis and other ocular diseases which may result from hypersensitivity to, or autoimmune reaction against, pigments of the uveal tract.
DAM 鸡系迟发性羽毛无黑变病和相关脉络膜缺陷发展过程中的进行性细胞学变化。
DOI：
--
发表时间：
1983
期刊：
The American journal of pathology
影响因子：
--
作者：
Boissy,RE;SmythJr,JR;Fite,KV
通讯作者：
Fite,KV
自发性糖尿病 BB 大鼠血-视网膜屏障的病理研究。
影响因子：
4.4
作者：
Blair,NP;Tso,MO;Dodge,JT
通讯作者：
Dodge,JT
影响因子：
4
作者：
Zigler, J. Samuel, Jr.;Zhang, Cheng;Sinha, Debasish
通讯作者：
Sinha, Debasish