Avian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates
Avian-to-human transmission of H9N2 subtype influenza A viruses: Relationship between H9N2 and H5N1 human isolates
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DOI：
10.1073/pnas.160270697
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发表时间：
2000-08-15
影响因子：
11.1
通讯作者：
Hay, A
中科院分区：
文献类型：
--
作者：
Lin, YP;Shaw, M;Hay, A
1997年，香港发生了18起由新型H5N1（鸡）病毒引起的流感（禽流感）病例，导致6人死亡，再次引发了可能造成毁灭性流感大流行的幽灵。在活禽市场屠宰家禽消除了传染源，没有再发生人类感染H5N1的病例。然而，1999年3月，一种新的大流行威胁出现了，当时甲型流感H9N2病毒感染了香港的两名儿童。这两种病毒分离株与一九九七年年底从香港一只鹌鹑身上分离出的H9N2病毒相似。虽然两者的表面血凝素和神经氨酸酶成分不同，但这两种H9N2病毒的一个显著特点是编码病毒内部成分的六个基因与一九九七年H5N1人类和禽类分离株的基因相似。这一共同特征强调了具有这种基因互补的禽类病毒感染人类的明显倾向，并突出了出现新型人类病原体的可能性。
In 1997, 18 cases of influenza in Hong Kong (bird flu) caused by a novel H5N1 (chicken) Virus resulted in the deaths of six individuals and once again raised the specter of a potentially devastating influenza pandemic. Slaughter of the poultry in the live bird markets removed the source of infection and no further human cases of H5N1 infection have occurred. In March 1999, however, a new pandemic threat appeared when influenza A H9N2 viruses infected two children in Hong Kong. These two virus isolates are similar to an H9N2 virus isolated from a quail in Hong Kong in late 1997, Although differing in their surface hemagglutinin and neuraminidase components, a notable feature of these H9N2 viruses is that the six genes encoding the internal components of the virus are similar to those of the 1997 H5N1 human and avian isolates. This common feature emphasizes the apparent propensity of avian viruses with this genetic complement to infect humans and highlights the potential for the emergence of a novel human pathogen.