Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life
Cognitive impairment among patients with multiple sclerosis: associations with employment and quality of life
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DOI：
10.1136/postgradmedj-2016-134071
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发表时间：
2017-03-01
影响因子：
5.1
通讯作者：
Langdon, D.
中科院分区：
文献类型：
--
作者：
Campbell, J.;Rashid, W.;Langdon, D.
目的 利用常规门诊多发性硬化症简要国际认知评估（BICAMS）探讨认知障碍与多发性硬化症（MS）常规残疾指标、生活质量（QOL）和就业状况之间的关系。方法采用 BICAMS 认知障碍测试组对 62 例 MS 患者进行认知障碍评估。获得了就业状况数据和完成的一些问卷，包括疲劳严重程度评分、多发性硬化症神经心理学问卷、医院焦虑和抑郁量表、多发性硬化症功能评估（FAMS）以及 EuroQOL 五维问卷（EQ-5D）。其他评估包括患者激活测量和多发性硬化症一维自我效能感量表。结果认知评估显示 44 名受试者 (65%) 在正式测试中存在认知障碍的证据。与没有认知障碍证据的患者相比，认知障碍患者的失业率显着更高（p=0.009）。符号数字模式测试是失业最重要的预测指标。认知障碍与 FAMS (p=0.001) 和 EQ-5D (p
Objectives To explore the relationship between cognitive impairment and conventional measures of disability in multiple sclerosis (MS), quality of life (QOL) and employment status using the brief international cognitive assessment for multiple sclerosis (BICAMS) in the routine outpatient clinic.Methods 62 patients with MS were assessed on the BICAMS test battery for cognitive impairment. Data were obtained on employment status and a number of questionnaires completed including fatigue severity score, multiple sclerosis neuropsychological questionnaire, hospital anxiety and depression scale, the functional assessment of multiple sclerosis (FAMS) as well as on the EuroQOL five dimension questionnaire (EQ-5D). Other assessments include the patient activation measure and unidimensional self-efficacy scale for multiple sclerosis.Results Cognitive assessment revealed 44 subjects (65%) had evidence of cognitive impairment on formal testing. In comparison with patients without evidence of cognitive impairment, cognitively impaired patients exhibited significantly higher rates of unemployment (p=0.009). The symbol digits modalities test was the most significant predictor of unemployment. Cognitive impairment was associated with lower QOL scores on the FAMS (p=0.001) and EQ-5D (p