Total synthesis of (±)-methyl-kinamycin C
Total synthesis of (±)-methyl-kinamycin C
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DOI：
10.1016/j.tet.2007.03.166
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发表时间：
2007-06-11
期刊：
影响因子：
2.1
通讯作者：
Ishikawa, Tsutomu
中科院分区：
文献类型：
--
作者：
Kumamoto, Takuya;Kitani, Yasuo;Ishikawa, Tsutomu
甲基基霉素C （methyl-kinamycin C，简称甲基-KC）是由甲基基霉素C衍生而来的，通过两个关键步骤：苯并茚酮和danishefsky型二烯的Diels-Alder反应，以及高氧D环的立体选择性构建，实现了甲基基霉素C结构的首次全合成。合成的标题化合物的光谱数据与天然KC及其衍生物的光谱数据吻合良好。(c) 2007 Elsevier Ltd.版权所有。
The first total synthesis of the proposed structure for methyl-kinamycin C (methyl-KC), derived from KC, was achieved via two key steps: Diels-Alder reaction of benzindenone and Danishefsky-type diene, and the stereoselective construction of highly oxygenated D ring. Good accordance of the spectral data of synthesized title compound with those of natural KC and its derivative was observed. (c) 2007 Elsevier Ltd. All rights reserved.