Long-Term Neurobiological Consequences of Early Postnatal hCMV-Infection in Former Preterms: A Functional MRI Study
Long-Term Neurobiological Consequences of Early Postnatal hCMV-Infection in Former Preterms: A Functional MRI Study
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DOI：
10.1002/hbm.22352
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发表时间：
2014-06-01
影响因子：
4.8
通讯作者：
Wilke, Marko
中科院分区：
文献类型：
--
作者：
Dorn, Maik;Lidzba, Karen;Wilke, Marko
出生后早期感染人巨细胞病毒（hCMV）可能导致早期早产儿（PT）的不良认知结局。我们在这里着手探讨是否长期的神经生物学后果，这种感染是可检测的使用功能磁共振成像在儿童和青少年谁出生非常早产，无论是谁（PThCMV+）或没有（PThCMV-）遭受出生后早期hCMV感染，当与典型的发展健康对照（HC）的主题。总体而言，可纳入71例儿童和青少年的数据，34例PT（其中15例为PT（hCMV+），19例为PT（hCMV-））和37例HC。使用最近建立的两用功能磁共振成像任务，我们调查的语言和视觉空间功能。在执行语言任务时，左侧海马（PT > HC和PThCMV+ > HC）和右侧前扣带皮层（PThCMV- > PThCMV+）的激活差异显著。令人惊讶的是，当执行视觉空间任务时，枕叶皮层中只有一个小区域显示出显著的激活差异（HC > PT（HCMV-））。有针对性的分析显示，在几个大脑区域中，灰质体积不同，但密度不同。我们的研究结果表明，出生后早期hCMV感染的长期神经生物学后果是可检测的，即使在年龄较大的儿童和青少年以前出生非常早产，兼容更高的努力时，执行认知任务。这表明有必要采取措施防止这种感染。此外，大脑结构和功能的相互关系被检测到，可能构成一个严重的混淆时，使用功能磁共振成像比较结构不同的群体。《脑地图》35：2594-2606，2014年。(c)2013 Wiley Periodicals，Inc.
Early postnatal infection with human cytomegalovirus (hCMV) may contribute to an adverse cognitive outcome in early preterm-born children (PT). We here set out to explore whether long-term neurobiological consequences of such an infection are detectable using fMRI in children and adolescents who were born very preterm and who either did (PThCMV+) or did not (PThCMV-) suffer from an early postnatal hCMV-infection, when compared with typically developing healthy control (HC) subjects. Overall, data from 71 children and adolescents could be included, 34 PT (of which 15 were PT (hCMV+) and 19 were PT (hCMV-)) and 37 HC. Using a recently established dual use fMRI task, we investigated language and visuospatial functions. There were significant activation differences in the left hippocampus (PT > HC and PThCMV+ > HC), and in the right anterior cingulate cortex (PThCMV- > PThCMV+) when performing the language task. Surprisingly, only a small region in the occipital cortex showed a significant activation difference (HC > PT (HCMV-)) when performing the visuospatial task. Targeted analyses revealed differences in gray matter volume, but not density, in several brain regions. Our results suggest that long-term neurobiological consequences of an early postnatal hCMV infection are detectable even in older children and adolescents formerly born very preterm, compatible with a higher effort when performing a cognitive task. This suggests that measures to prevent such an infection are warranted. Furthermore, an interrelation of brain structure and function was detected that may constitute a severe confound when using fMRI to compare structurally differing groups. Hum Brain Mapp 35:2594-2606, 2014. (c) 2013 Wiley Periodicals, Inc.