Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms.
Youth-associated platelet-derived chemokine reverses brain aging through neuroimmune mechanisms.
复制标题
青少年相关的血小板衍生趋化因子通过神经免疫机制逆转大脑衰老。
DOI：
10.1016/j.molmed.2023.10.007
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发表时间：
2024
影响因子：
13.6
通讯作者：
Castellano,JosephM
中科院分区：
文献类型：
--
作者：
Hemmer,BrittanyM;Philippi,SarahM;Castellano,JosephM
脑功能的丧失被认为是不可避免的，但最近利用系统环境的工作挑战了这一概念。Schroer等人证明，青年相关血小板因子4（PF4）部分恢复老年小鼠的脑功能，同时减少外周免疫功能障碍，支持基于外周的方法来治疗年龄相关的脑部疾病。
Age-related loss of brain function has been seen as inevitable, yet recent work leveraging the systemic environment challenges this notion. Schroer et al. demonstrate that youth-associated platelet factor 4 (PF4) partially restores brain function in aged mice while reducing peripheral immune dysfunction, supporting periphery-based approaches to treat age-associated brain disorders.